A new cure rate frailty regression model based on a weighted Lindley distribution applied to stomach cancer data

Author(s)

Mota, Alex ; Milani, Eder A. ; Leao, Jeremias ; Ramos, Pedro L. ; Ferreira, Paulo H. ; Junior, Oilson G. ; Tomazella, Vera L. D. ; Louzada, Francisco

• Document type: Journal article
• Source: Statistical Methods and Applications; v. N/A, p. 27-pg., 2022-11-17.

Abstract

In this paper, we propose a new cure rate frailty regression model based on a two-parameter weighted Lindley distribution. The weighted Lindley distribution has attractive properties such as flexibility on its probability density function, Laplace transform function on closed-form, among others. An advantage of proposed model is the possibility to jointly model the heterogeneity among patients by their frailties and the presence of a cured fraction of them. To make the model parameters identifiable, we consider a reparameterized version of the weighted Lindley distribution with unit mean as frailty distribution. The proposed model is very flexible in sense that has some traditional cure rate models as special cases. The statistical inference for the model's parameters is discussed in detail using the maximum likelihood estimation under random right-censoring. Further, we present a Monte Carlo simulation study to verify the maximum likelihood estimators' behavior assuming different sample sizes and censoring proportions. Finally, the new model describes the lifetime of 22,148 patients with stomach cancer, obtained from the Fundacao Oncocentro de Sao Paulo, Brazil. (AU)

• FAPESP's process: 13/07375-0 - CeMEAI - Center for Mathematical Sciences Applied to Industry
• Grantee: Francisco Louzada Neto
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC