The Inflammation Level and a Microbiological Analysis of the Anophthalmic Cavities of Unilateral Ocular Prosthesis Users: A Blind, Randomized Observational Study

Author(s)

Penitente, Paulo Augusto ; Freitas Da Silva, Emily Vivianne ; Goiato, Marcelo Coelho ; Pontes Manicoba, Lorena Louise ; Balera Brito, Victor Gustavo ; Leal Turcio, Karina Helga ; Rodrigues, Alana Semenzin ; Nagay, Bruna Egumi ; Dos Santos, Daniela Micheline

• Document type: Journal article
• Source: ANTIBIOTICS-BASEL; v. 11, n. 11, p. 16-pg., 2022-11-01.

Abstract

Irritation and biofilm adhesion are complaints associated with ocular prosthesis use. This study aimed to evaluate the effects of prosthesis repolishing on several conditions of anophthalmic volunteers. Participants were divided into two groups: intervention (IG, n = 10) and nonintervention (NIG, n = 6) groups. The anophthalmic cavity, contralateral eye, and prosthesis surface were evaluated at initial, day 15, and day 30 after repolishing. Microbiological analysis (colony-forming units), exfoliative cytology (conjunctiva inflammatory cells), sensory analysis (quantitative mechanical sensory test), tear production (Schirmer's test), and conjunctival inflammation (clinical evaluation) were performed. Nonparametric tests were used to compare groups in the initial period and to analyze periods for the IG (p < 0.05). More microorganisms were formed in the anophthalmic socket and prosthesis than in the contralateral eye in the initial period. For IG, the anophthalmic cavity exhibited more microorganisms and inflammatory clinical signs in the initial period than at 15 and 30 after repolishing. The prosthesis showed greater accumulations of total bacteria and Candida albicans in the initial period than at 15 and 30 days after repolishing. The anophthalmic cavity had more palpebral inflammation than the contralateral eye. In conclusion, repolishing reduced the number of microorganisms and inflammatory signs over time. (AU)

• FAPESP's process: 19/07295-2 - Anophthalmic cavity inflammation level and microbiological analysis of unilateral ocular prostheses users
• Grantee: Paulo Augusto Penitente
• Support Opportunities: Scholarships in Brazil - Master