A deep learning approach for COVID-19 screening and localization on Chest X-Ray images

Author(s)

Marcomini, Karem Daiane ; Cardona Cardenas, Diego Armando ; Machado Traina, Agma Juci ; Krieger, Jose Eduardo ; Gutierrez, Marco Antonio ; Drukker, K ; Iftekharuddin, KM

• Document type: Journal article
• Source: MEDICAL IMAGING 2022: COMPUTER-AIDED DIAGNOSIS; v. 12033, p. 9-pg., 2022-01-01.

Abstract

Chest X-ray (CXR) images have a high potential in the monitoring and examination of various lung diseases, including COVID-19. However, the screening of a large number of patients with diagnostic hypothesis for COVID-19 poses a major challenge for physicians. In this paper, we propose a deep learning-based approach that can simultaneously suggest a diagnose and localize lung opacity areas in CXR images. We used a public dataset containing 5, 639 posteroanterior CXR images. Due to unbalanced classes (69.2% of the images are COVID-19 positive), data augmentation was applied only to images belonging to the normal category. We split the dataset into train and test sets with proportional rate at 90:10. To the classification task, we applied 5-fold cross-validation to the training set. The EfficientNetB4 architecture was used to perform this classification. We used a YOLOv5 pre-trained in COCO dataset to the detection task. Evaluations were based on accuracy and area under the ROC curve (AUROC) metrics to the classification task and mean average precision (mAP) to the detection task. The classification task achieved an average accuracy of 0.83 +/- 0.01 (95% CI [0.81, 0.84]) and AUC of 0.88 +/- 0.02 (95% CI [0.85, 0.89]) in 5-fold over the test dataset. The best result was reached in fold 3 (0.84 and 0.89 of accuracy and AUC, respectively). Positive results were evaluated by the opacity detector, which achieved a mAP of 59.51%. Thus, the good performance and rapid diagnostic prediction make the system a promising means to assist radiologists in decision making tasks. (AU)

• FAPESP's process: 20/07200-9 - Analyzing complex data from COVID-19 to support decision making and prognosis
• Grantee: Agma Juci Machado Traina
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/17078-0 - Mining, indexing and visualizing Big Data in clinical decision support systems (MIVisBD)
• Grantee: Agma Juci Machado Traina
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 20/14180-4 - Development of radiographic quantitative markers for Precision Medicine regarding acute respiratory syndrome
• Grantee: Karem Daiane Marcomini
• Support Opportunities: Scholarships in Brazil - Post-Doctoral