Bauhinia forficata link extract attenuates insulin resistance by preserving glucose uptake in gastrocnemius muscle

Author(s)

Gasparini, Patricia ; Garofolo, Ingrid Candido ; Telles, Monica Marques ; Oyama, Lila Missae ; Veneza, Viviane de Mello ; Moura Veiga, Thiago Andre ; Flor Silveira, Vera Lucia ; Caperuto, Luciana Chagas

• Document type: Journal article
• Source: NATURAL PRODUCT RESEARCH; v. N/A, p. 6-pg., 2022-08-16.

Abstract

Bioactive metabolites from Bauhinia forficata Link (Bf extract) hold therapeutic potential for type 2 diabetes mellitus (T2DM) but the mechanism remains poorly understood. This study aimed to test the extract from Bf leaves obtained by decoction on the prevention of T2DM in vivo. The Bf extract was tested on a streptozotocin-induced T2DM mouse model fed on a high-fat diet. The insulin resistance was attenuated in T2DM animals supplemented with Bf extract, which indicates glucose intolerance reduction and p-AKT/AKT ratio preservation in the gastrocnemius muscle. These observations suggested that Bf extract enhanced glucose uptake. Nevertheless, there was no preservation in beta-cell insulin secretion in Bf extract-treated T2DM mice. Interestingly, the Bf extract reduced body weight gain without affecting total energy intake. Hence, Bf extract has a hypoglycemic effect which could attenuate the development of insulin resistance. (AU)

• FAPESP's process: 17/02936-4 - Effect of omega 3 poliinsaturated fatty acids on quality of oocytes and fertility in mice with type 2 Diabetes
• Grantee: Vera Lucia Flor Silveira
• Support Opportunities: Regular Research Grants