| Full text | |
| Author(s): |
Joaquim, Victor Hugo Antonio
;
Pereira, Noemy Pinto
;
Fernandes, Tiago
;
Oliveira, Edilamar Menezes
Total Authors: 4
|
| Document type: | Journal article |
| Source: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 24, n. 3, p. 16-pg., 2023-02-01. |
| Abstract | |
Circular RNAs (circRNAs) are a family of noncoding RNAs (ncRNAs) that are endogenous and widely distributed in different species, performing several functions, mainly their association with microRNAs (miRNAs) and RNA-binding proteins. CVDs remain the leading cause of death worldwide; therefore, the development of new therapies and strategies, such as gene therapies or nonpharmacological therapies, with low cost, such as physical exercise, to alleviate these diseases is of extreme importance for society. With increasing evidence of ncRNA participating in the progression of CVDs, several studies have reported these RNAs as promising targets for diagnosis and treatment. There are several studies of CVDs and the role of miRNAs and lncRNAs; however, little is known about the new class of RNAs, called circRNAs, and CVDs. In this mini review, we focus on the mechanisms of circRNAs and CVDs. (AU) | |
| FAPESP's process: | 15/22814-5 - Cancer and heart: new paradigms of diagnosis and treatment |
| Grantee: | Carlos Eduardo Negrão |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 22/00531-5 - Novel therapies for myocardial infarct: the role of physical training and novel circular RNAs |
| Grantee: | Edilamar Menezes de Oliveira |
| Support Opportunities: | Scholarships abroad - Research |
| FAPESP's process: | 18/22579-4 - Exosomal microRNAs as circulating biomarkers and mediators of the cardioprotective effect in patients undergoing cancer therapies |
| Grantee: | Edilamar Menezes de Oliveira |
| Support Opportunities: | Regular Research Grants |