Bone, fat, and muscle interactions in health and disease

Author(s)

Gomes, Mayra Macena ; Rodrigues da Silva, Maisa Monseff ; de Araujo, Iana Mizumukai ; Albuquerque de Paula, Francisco Jose

• Document type: Journal article
• Source: ARCHIVES OF ENDOCRINOLOGY METABOLISM; v. 66, n. 5, p. 10-pg., 2022-09-01.

Abstract

Energy metabolism is a point of integration among the various organs and tissues of the human body, not only in terms of consumption of energy substrates but also because it concentrates a wide interconnected network controlled by endocrine factors. Thus, not only do tissues consume substrates, but they also participate in modulating energy metabolism. Soft mesenchymal tissues, in particular, play a key role in this process. The recognition that high energy consumption is involved in bone remodeling has been accompanied by evidence showing that osteoblasts and osteocytes produce factors that influence, for example, insulin sensitivity and appetite. Additionally, there are significant interactions between muscle, adipose, and bone tissues to control mutual tissue trophism. Not by chance, trophic and functional changes in these tissues go hand in hand from the beginning of an individual's development until aging. Likewise, metabolic and nutritional diseases deeply affect the musculoskeletal system and adipose tissue. The present narrative review highlights the importance of the interaction of the mesenchymal tissues for bone development and maintenance and the impact on bone from diseases marked by functional and trophic disorders of adipose and muscle tissues. (AU)

• FAPESP's process: 18/18071-5 - Hydroelectrolytic and energy homeostasis: from cellular metabolism to endocrine systems in different phases of development
• Grantee: Lucila Leico Kagohara Elias
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 21/03152-2 - Interaction between fat, muscle, and bone tissues in anorexia nervosa
• Grantee: Iana Mizumukai de Araujo
• Support Opportunities: Scholarships in Brazil - Post-Doctoral