Recent advances on paper-based microfluidic devices for bioanalysis

Author(s)

Silva-Neto, Habdias A. ; Arantes, Iana V. S. ; Ferreira, Andre L. ; do Nascimento, Guida H. M. ; Meloni, Gabriel N. ; de Araujo, William R. ; Paixa, Thiago R. L. C. ; Coltro, Wendell K. T.

• Document type: Journal article
• Source: TRAC-TRENDS IN ANALYTICAL CHEMISTRY; v. 158, p. 25-pg., 2022-12-27.

Abstract

Paper-based microfluidic devices have emerged as powerful platforms for bioanalysis offering advan-tages over other substrate materials including simpler fabrication protocols, compatibility with multi-purpose detectors, and global affordability. This review presents and discusses important information related to manufacturing methods, integrative sensing materials, the clinical relevance of biomarkers and bioanalysis. Examples of applications involving invasive and non-invasive samples, such as human serum, plasma, saliva, sweat, and urine are highlighted. Also, this review covers examples of (bio)sensing applications including the detection of viruses, microorganisms, neurodegenerative, cancer, diabetes, and allergic diseases. Lastly, the review summarizes recent examples of paper-based wearable devices and hybrid sensors dedicated to clinical applications and challenging points that can be carefully observed for the next generation of paper-based microfluidic sensors. (AU)

• FAPESP's process: 19/15065-7 - Development of paper-based electrochemical systems aiming flow analysis of forensic samples
• Grantee: Iana Vitória Spadini Arantes
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 22/03382-0 - Wearable sensor for real time monitoring of drugs of abuse in human saliva
• Grantee: Gabriel Negrão Meloni
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 18/08782-1 - Miniaturized and integrated chemical sensors: new fabrication platforms for biological, clinical and environmental applications
• Grantee: Mauro Bertotti
• Support Opportunities: Research Projects - Thematic Grants