| Full text | |
| Author(s): |
Abucafy, Marina Paiva
;
Galvao Frem, Regina Celia
;
Polinario, Giulia
;
Pavan, Fernando Rogerio
;
Zhao, Heng
;
Mielcarek, Angelika
;
Boissiere, Cedric
;
Serre, Christian
;
Chiavacci, Leila Aparecida
Total Authors: 9
|
| Document type: | Journal article |
| Source: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 23, n. 14, p. 15-pg., 2022-07-01. |
| Abstract | |
Nanoparticles of metal-organic frameworks (MOF NPs) are crystalline hybrid micro- or mesoporous nanomaterials that show great promise in biomedicine due to their significant drug loading ability and controlled release. Herein, we develop porous capsules from aggregate of nanoparticles of the iron carboxylate MIL-100(Fe) through a low-temperature spray-drying route. This enables the concomitant one-pot encapsulation of high loading of an antitumor drug, methotrexate, within the pores of the MOF NPs, and the collagenase enzyme (COL), inside the inter-particular mesoporous cavities, upon the formation of the capsule, enhancing tumor treatment. This association provides better control of the release of the active moieties, MTX and collagenase, in simulated body fluid conditions in comparison with the bare MOF NPs. In addition, the loaded MIL-100 capsules present, against the A-375 cancer cell line, selective toxicity nine times higher than for the normal HaCaT cells, suggesting that MTX@COL@MIL-100 capsules may have potential application in the selective treatment of cancer cells. We highlight that an appropriate level of collagenase activity remained after encapsulation using the spray dryer equipment. Therefore, this work describes a novel application of MOF-based capsules as a dual drug delivery system for cancer treatment. (AU) | |
| FAPESP's process: | 16/11563-4 - Supramolecular capsules based on metal-organic framework applied for drug release |
| Grantee: | Marina Paiva Abuçafy |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 18/00442-7 - Advanced synthesis of nanocapsules based on biocompatible metal- organic frameworks as advanced drug delivery system |
| Grantee: | Marina Paiva Abuçafy |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |