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Development of hybrid theranostic systems

Grant number: 17/21456-3
Support type:Regular Research Grants
Duration: April 01, 2018 - March 31, 2020
Field of knowledge:Engineering - Materials and Metallurgical Engineering
Principal Investigator:Leila Aparecida Chiavacci Favorin
Grantee:Leila Aparecida Chiavacci Favorin
Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Assoc. researchers:Eloísa Berbel Manaia

Abstract

The specific release of active molecules presents a major challenge for the treatment of several diseases, in particular cancer. The active molecules must be able to overcome barriers separating them from the site of administration or the desired site of action. For this, carrier and controlled drug delivery systems have been used. In addition to the vectorization of active molecules to specific sites of action, these systems provide greater therapeutic efficacy and stability by reducing side effects in several treatments. The materials that are currently used for this purpose have as main limitation the low capacity to carry large mass of drug. To overcome this limitation new classes of materials are being developed, such as metallo-organic networks and lipid nanocapsules. The most innovative research is in the design of "theranostic" systems that combine a diagnostic function, thanks to the image, and a therapeutic function, thanks to the vectorization of an active principle. The aim of this project is to develop hybrid theranostic systems, formed by a phase junction based on metals such as Gd, Mn, Co, Fe and Eu with luminescent and / or magnetic properties and an organic release system, capable of containing large amounts of active molecules. Thus, in this project we intend to develop and characterize lipid nanocapsules and metallo-organic networks for diagnostic and to control the release of biologically active molecules. On the one hand, lipid nanocapsules will be developed by the phase inversion method with known efficiency in the controlled release and vectorization of drugs containing zinc oxide-based quantum dots with Mn, Co and Gd for simultaneous use in diagnostic imaging and transport of biologically active molecules. On the other hand, it is intended to develop metallo-organic networks formed by Fe and Eu metal ions and by different organic binders such as tannic acid, trimesic acid and 1,4-benzenedicarboxylic acid.The objectives proposed above are in the context of a PhD project of Marina Paiva Abuçafy, currently supported by FAPESP, project 2016 / 11563-4 entitled "Supramolecular capsules derived from metallo-organic networks for drug release". In addition, this project also includes the continuation of the research activities carried out by the researcher responsible for this proposal, during a research internship between 06/2016 and 06/2017 at the Faculty of Medicine of the University of Angers in Angers- France, also supported by FAPESP, project 2014 / 26671-1 entitled "Development of ZnO-based thermostatic systems and lipid nanocapsules", and consists of a complementation of the previously proposed objectives. In this way, this project also represents the continuity of work in collaboration with the Université de Angers, which will contribute to the formation of highly qualified human resources through the completion of post-doctoral theses and internships in collaboration with the French University. (AU)