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Characterization of Mg-doped ZnO quantum dots and liposomes containing QDs

Grant number: 15/01198-4
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): April 09, 2015
Effective date (End): June 08, 2015
Field of knowledge:Engineering - Materials and Metallurgical Engineering
Principal Investigator:Leila Aparecida Chiavacci Favorin
Grantee:Eloísa Berbel Manaia
Supervisor abroad: Claudie Bourgaux
Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Local de pesquisa : Université Paris-Sud (Paris 11), France  
Associated to the scholarship:12/07570-4 - Zinc based quantum dots and double salts incorporated in liposome for image and vectorization of anticancer drug, BP.DR

Abstract

Nanocrystals of ZnO are currently attracting great interest as potential labels for biological applications, such as theranostic devices, due to their luminescent properties and low toxicity in vivo. It has been reported that doping with Mg2+ ions could enhance the luminescence of ZnO Quantum Dots (QDs). In the project of thesis of the candidate Mg-doped ZnO QDs were synthesized by a hydrolysis and condensation reaction. Surface modification of the QDs was performed using oleic acid (OA) and citric acid (CA) to hinder their aggregation and to provide them colloidal stability in non-polar and polar environments, respectively. The oleic acid surface modifieid Mg-doped and undoped ZnO QDs were incorporated in lipid systems keeping the luminescence properties of the QDs. The aim of this internship is to identify where the dopant is inserted in the ZnO strucuture by EXAFS measurements, to characterize the structure of the lipid sytems by SAXS measurements, to perform the confocal microscopy to visualize the cell internalization of the nanoparticles and to evaluate their luminescence properties in bioimaging applications. This internship is crucial for the conclusion of the studies related to the thesis of the project "Zinc based quantum dots and double salts incorporated in liposome for image and vectorization of anticancer drug", FAPESP Process 2012/07570-4. (AU)

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