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Development of terostatic systems based on ZnO doped with GD, Mn, Co and lipidic nanocapsules

Grant number: 17/16074-4
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): April 01, 2018
Effective date (End): February 02, 2022
Field of knowledge:Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
Principal Investigator:Leila Aparecida Chiavacci Favorin
Grantee:Bruna Lallo da Silva
Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated scholarship(s):18/14164-9 - Development of theranostic self-assemblies based on quantum dots and ferrocene, BE.EP.DR

Abstract

The use of lipid-based nanocarriers such as lipid nanocapsules has attracted attention because it is a safe system to be used as controlled drug release and diagnostic imaging. In recent years, ZnO Quantum Dots (QDs) are being used to obtain biological images for its excellent luminescent properties and the possibility of incorporating contrast agents for application in magnetic resonance such as gadolinium, manganese and cobalt allows the association of two imaging techniques (optics and resonance) in a single nanostructure. Therefore, the objective of this work is develop ZnO QDs with different dopants (Gd, Co, Mn) and incorporate them in NCL so the developed nanocarrier be able to attach diagnostic properties through images obtained by fluorescence and magnetic resonance and therapeutic properties by the possibility of drug delivery. The ZnO QDs will be obtained by the sol-gel process and doped with different metals and then, will incorporated into the NCL synthesized by the phase inversion method. The teranostic systems will be characterized by techniques of quantum yield and magnetic resonance. "In vitro" and "ex vivo" assays will be used to evaluate cytotoxicity and the cell internalization using fluorescence microscopy and magnetic resonance and "in vivo" magnetic resonance imaging in small animals (non-invasive tests). (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA, BRUNA LALLO; LEMAIRE, LAURENT; BENOIT, JEAN-PIERRE; BORGES, FERNANDA HEDIGER; GONCALVES, ROGERIA ROCHA; AMANTINO, CAMILA FERNANDA; PRIMO, FERNANDO LUCAS; CHIAVACCI, LEILA APARECIDA. Magnetic and Highly Luminescent Heterostructures of Gd3+/ZnO Conjugated to GCIS/ZnS Quantum Dots for Multimodal Imaging. NANOMATERIALS, v. 11, n. 7, . (18/14164-9, 17/21456-3, 17/16074-4)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Bruna Lallo da. Desenvolvimento de pontos quânticos de Gd3+/ZnO conjugados a pontos quânticos de GCIS/ZnS para imagens multimodais associados à nanocápsulas lipídicas. 2022. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Farmacêuticas. Araraquara Araraquara.

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