Bergamot leaf extract treats cardiorenal metabolic syndrome and associated pathophysiological factors in rats fed with a high sugar fat diet

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Siqueira, Juliana Silva ; Vieira, Taynara Aparecida ; Nakandakare-Maia, Erika Tiemi ; Novaga Palacio, Thiago Luiz ; Sarzi, Felipe ; Garcia, Jessica Leite ; de Paula, Bruno Henrique ; Zanati Bazan, Silmeia Garcia ; Baron, Giovanna ; Tucci, Luigi ; Janda, Elzbieta ; Altomare, Alessandra ; Gado, Francesca ; Togneri Ferron, Artur Junio ; Aldini, Giancarlo ; Francisqueti-Ferron, Fabiane Valentini ; Correa, Camila Renata

• Document type: Journal article
• Source: Molecular and Cellular Endocrinology; v. 556, p. 10-pg., 2022-08-05.

Abstract

Bergamot citrus (Citrus bergamia Risso et Poiteau), have been used as a strategy to prevent or treat comorbidities associated with metabolic syndrome parameters, such as cardiorenal metabolic syndrome (CRMS). The aim was to test the effect of bergamot leaf extract on CRMS and associated pathophysiological factors in rats fed with a high sugar-fat diet. Animals were divided into two experimental groups with control diet (Control, n = 30) and high sugar-fat diet (HSF, n = 30) for 20 weeks. Once CRMS was detected, animals were redivided to begin the treatment with Bergamot Leaf Extract (BLE) by gavage (50 mg/kg) for 10 weeks: control diet + placebo (Control, n = 09), control diet + BLE (Control + BLE, n = 09), HSF diet + placebo (HSF, n = 09), HSF + BLE (n = 09). Evaluation included nutritional, metabolic and hormonal analysis; and renal and cardiac parameters. HSF groups presented obesity, dyslipidemia, hypertension, hyperglycemia, hyperinsulinemia, insulin resistance. BLE showed protection against effects on hypertriglyceridemia, insulin resistance, renal damage, and structural and functional alterations of the heart. Conclusion: Bergamot leaf extract shows potential as a therapeutic to treat CRMS in animals fed with a high sugar-fat diet. (AU)

• FAPESP's process: 18/15294-3 - Influence of gamma-orizanol intervention on the prevention of cardiorreanal metabolic syndrome in obese rats: participation of protein carbonylation
• Grantee: Camila Renata Corrêa
• Support Opportunities: Regular Research Grants