Pouchitis: insight into the pathogenesis and clinical aspects

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Vidal de Negreiros, Leandro Minatel ; Pascoal, Livia Bitencourt ; Genaro, Livia Moreira ; Silva, Julian Furtado ; Rodrigues, Bruno Lima ; Camargo, Michel Gardere ; Real Martinez, Carlos Augusto ; Rodrigues Coy, Claudio Saddy ; Setsuko Ayrizono, Maria de Lourdes ; Fagundes, Joao Jose ; Leal, Raquel Franco

• Document type: Journal article
• Source: AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH; v. 14, n. 7, p. 20-pg., 2022-01-01.

Abstract

Ulcerative colitis (UC) is a chronic intestinal inflammatory disease and familial adenomatous polyposis (FAP) is an autosomal dominant inherited disease. Both diseases, despite being different, may require the same surgical procedure: proctocolectomy with ileal pouch-anal anastomosis (IPAA). The main complication after this procedure is pouch inflammation (pouchitis). This inflammatory complication can affect up to 60 percent of patients who receive IPAA for UC, and a very small percentage of the FAP patients. The purpose of this review was to determine the current molecular mechanisms in its pathogenesis and detail the risk factors involved in pouchitis, its diagnosis, and treatment. (AU)

• FAPESP's process: 20/01924-5 - Evaluation of Adalimumab plasma levels and detection of anti-Adalimumab antibodies in patients with Crohn's Disease
• Grantee: Livia Moreira Genaro
• Support Opportunities: Scholarships in Brazil - Doctorate