Head and neck squamous cell carcinoma: Exploring frontiers of combinatorial approaches with tyrosine kinase inhibitors and immune checkpoint therapy

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Scarini, Joao Figueira ; Lavareze, Luccas ; de Lima-Souza, Reydson Alcides ; Emerick, Carolina ; Goncalves, Mayara Trevizol ; Figueiredo-Maciel, Tayna ; Vieira, Gustavo de Souza ; Kimura, Talita de Carvalho ; de Sa, Raisa Sales ; Aquino, Iara Goncalves ; Fernandes, Patricia Maria ; Kowalski, Luiz Paulo ; Altemani, Albina ; Mariano, Fernanda Viviane ; Abu Egal, Erika Said

• Document type: Journal article
• Source: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY; v. 180, p. 14-pg., 2022-12-01.

Abstract

Squamous cell carcinomas (SCC) are the most common malignant tumors that arise in the head and neck. Despite advances in the management of affected patients, the mortality burden of these tumors is increasing every year. The discovery of a vast genetic landscape has revealed new opportunities for therapeutic intervention of head and neck SCC (HNSCC). Molecular alterations of tyrosine kinases are involved in the pathogenesis of cancer and may help keep cancer cells from growing. Currently, many drugs inhibit this enzyme family and are being studied by the pharmaceutical industry opening the room to expand the use and efficacy of this therapeutic modality alone or using combinatorial approaches including checkpoint inhibitors for treatment. In this paper, we explored the role of tyrosine kinases inhibitors of HNSCC, and clinical trials related to these molecules, expecting to provide references for HNSCC therapy. (AU)

• FAPESP's process: 15/07304-0 - Study of genetic and metabolic changes of pleomorphic adenoma and carcinoma ex pleomorphic adenoma by exome, gene expression and immunohistochemistry
• Grantee: Fernanda Viviane Mariano Brum Corrêa
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 21/12567-1 - Validation of potential genomic alterations found during the malignant transformation of the pleomorphic adenoma
• Grantee: João Figueira Scarini
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 19/09419-0 - Genomic alterations in the malignant transformation of the Pleomorphic Adenoma
• Grantee: João Figueira Scarini
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 19/06809-2 - Analysis of mass spectrometry in the malignant transformation of the pleomorphic adenoma. correlation of data with gene expression and exome
• Grantee: Reydson Alcides de Lima Souza
• Support Opportunities: Scholarships in Brazil - Master