Recurrence Quantification Analysis for Investigating Atrial Fibrillation Dynamics in a Heterogeneous Simulation Setup

Author(s)

Almeida, Tiago P. ; Unger, Laura A. ; Soriano, Diogo C. ; Li, Xin ; Doessel, Olaf ; Yoneyama, Takashi ; Loewe, Axel ; IEEE

• Document type: Journal article
• Source: 2019 41ST ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC); v. N/A, p. 4-pg., 2019-01-01.

Abstract

The outcomes of ablation targeting either reentry activations or fractionated activity during persistent atrial fibrillation (AF) therapy remain suboptimal due to, among others, the intricate underlying AF dynamics. In the present work, we sought to investigate such AF dynamics in a heterogeneous simulation setup using recurrence quantification analysis (RQA). AF was simulated in a spherical model of the left atrium, from which 412 unipolar atrial electrograms (AEGs) were extracted (2 s duration; 5 mm spacing). The phase was calculated using the Hilbert transform, followed by the identification of points of singularity (PS). Three regions were defined according to the occurrence of PSs: 1) no rotors; 2) transient rotors and; 3) long-standing rotors. Bipolar AEGs (1114) were calculated from pairs of unipolar nodes and bandpass filtered (30-300 Hz). The CARTO criterion (Biosense Webster) was used for AEGs classification (normal vs. fractionated). RQA attributes were calculated from the filtered bipolar AEGs: determinism (DET); recurrence rate (RR); laminarity (LAM). Sample entropy (SampEn) and dominant frequency (DF) were also calculated from the AEGs. Regions with long-standing rotors have shown significantly lower RQA attributes and SampEn when compared to the other regions, suggesting a higher irregular behaviour (P <= 0.01 for all cases). Normal and fractionated AEGs were found in all regions (respectively; Region 1: 387 vs. 15; Region 2: 221 vs. 13; Region 3: 415 vs. 63). Region 1 vs. Region 3 have shown significant differences in normal AEGs (P <= 0.0001 for all RQA attributes and SampEn), and significant differences in fractionated AEGs for LAM, RR and SampEn (P=0.0071, P=0.0221 and P=0.0086, respectively). Our results suggest the co-existence of normal and fractionated AEGs within long-standing rotors. RQA has unveiled distinct dynamic patterns-irrespective of AEGs classification-related to regularity structures and their nonstationary behaviour in a rigorous deterministic context. (AU)

• FAPESP's process: 18/02251-4 - Characterizing persistent atrial fibrillation dynamics using computational models and recurrence quantification analysis - towards novel biomarkers for guiding therapy
• Grantee: Tiago Paggi de Almeida
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• FAPESP's process: 17/00319-8 - Atrial substrate identification in patients with chronic atrial fibrillation using multivariate statistical models and multiple attributes from atrial electrograms
• Grantee: Tiago Paggi de Almeida
• Support Opportunities: Scholarships in Brazil - Post-Doctoral