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Removal of Amoxicillin from Processing Wastewater by Ozonation and UV-Aided Ozonation: Kinetic and Economic Comparative Study

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Author(s):
Silva, Beatriz Santos ; Barros Ribeiro, Mariana Cardoso ; Ramos, Bruno ; de Castro Peixoto, Andre Luis
Total Authors: 4
Document type: Journal article
Source: WATER; v. 14, n. 20, p. 18-pg., 2022-10-01.
Abstract

This work presents an empirical and scaling-up study of the degradation and mineralization of amoxicillin (AMX) from expired pharmaceutical formulations by O-3-based processes. A set of UV-ozone-based experiments was used to model the kinetics of AMX degradation, considering several chemical/photochemical mechanisms (hydrolysis, direct ozonation, radical reactions, and photolysis). Finally, the modeling data were used for scaling-up purposes, considering CAPEX and OPEX costs on the US Gulf Coast basis. In terms of experimental results, the amoxicillin (AMX) pharmaceutical effluent was successfully degraded by ozone technology at high pH values. The semi-batch ozonation process was effective after 60 min of treatment in all experimental conditions, producing degradation intermediates recalcitrant to O-3 oxidative process. From the bench-scale kinetics, scaling-up simulations indicate that the gain provided by adding a UV unit does not compensate for the increase in capital and operational costs of adding irradiation equipment. It suggests ozonation at high pH as the best cost-effective approach to degrade AMX. The figures-of-merit electric energy consumption per order (E-EO) corroborates the scaling-up simulations. E-EO results indicate no-UV ozonation as the best option to degrade AMX at high pH values. The E-EO of the present work showed a lower energy consumption system than previous papers from the literature. (AU)

FAPESP's process: 19/09991-6 - Degradation of expired drug compositions containing amoxicillin by H2O2/UV, O3/UV, and hybrid H2O2/O3/UV processes: intensification of processes and economic evaluation
Grantee:Mariana Cardoso Barros Ribeiro
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 18/05698-0 - Advanced Oxidation Processes Applied in Expired Drug Degradation Containing Amoxicillin: Chemical and Economical Approach
Grantee:André Luís de Castro Peixoto
Support Opportunities: Regular Research Grants
FAPESP's process: 21/03446-6 - Development of a hybrid O3/H2O2 -adsorption process for the removal of amoxicillin from effluents: application of moringa oleifera biomass and process intensification
Grantee:Beatriz Santos Silva
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 18/17913-2 - Multi-user equipment approved in grant 18/05698-0: Total Organic Carbon (TOC) analyzer
Grantee:André Luís de Castro Peixoto
Support Opportunities: Multi-user Equipment Program