Features of lumbar spine texture extracted from routine MRI correlate with bone mineral density and can potentially differentiate patients with and without fragility fractures in the spine

Author(s)

Maciel, J. G. ; Salmon, C. E. G. ; Hosseini, B. S. ; Azevedo-Marques, P. M. ; de Paula, F. J. A. ; Nogueira-Barbosa, M. H.

• Document type: Journal article
• Source: Brazilian Journal of Medical and Biological Research; v. 56, n. 1, p. 7-pg., 2022-01-01.

Abstract

The use of routine magnetic resonance imaging (MRI) to potentially assess skeletal fragility has been widely studied in osteoporosis. The aim of this study was to evaluate bone texture attributes (TA) from routine lumbar spine (LS) MRI and their correlation with vertebral fragility fractures (VFF) and bone mineral density (BMD). Sixty-four post-menopausal women were submitted to LS densitometry, total spine radiographs, and routine T2-weighted LS MRI. Twenty-two TA were extracted with the platform IBEX from L3 vertebra. The statistical difference was evaluated using ANOVA and Duncan's post-test. Correlation analyses were performed using Spearman's coefficient. Statistical significance was considered when Po0.05. The results did not show a significant difference in BMD between the women with and without fractures. Two bone TA (cluster tendency and variance) were significantly lower in the fracture group. Cluster tendency with VFF in osteopenia was 1.54 +/- 1.37 and in osteoporosis was 1.11 +/- 58. Cluster tendency without VFF in osteopenia was 2.23 +/- 1.38 and in osteoporosis was 1.88 +/- 1.14). Variance with VFF in osteopenia was 1.44 +/- 1.37 and in osteoporosis was 1.13 +/- 59. Variance without VFF in osteopenia was 2.34 +/- 1.38 and in osteoporosis was 1.89 +/- 1.14. There was a significant correlation between BMD and cluster prominence (r=0.409), cluster tendency (r=0.345), correlation (r=0.570), entropy (r=0.364), information measure corr1 (r=0.378), inverse variance (r=0.449), sum entropy (r=0.320), variance (r=0.338), sum average (r=-0.274), and sum variance (r=-0.266). Our results demonstrated the potential use of TA extracted from routine MRI as a biomarker to assess osteoporosis and identify the tendency of skeletal fragility vertebral fractures. (AU)

• FAPESP's process: 18/04266-9 - Multiparametric analysis of lumbar vertebrae texture on magnetic resonance imaging and correlation with fragility fractures.
• Grantee: Marcello Henrique Nogueira Barbosa
• Support Opportunities: Regular Research Grants