| Full text | |
| Author(s): |
Souto, Fernanda Maria Silveira
;
Missaka, Ruy Felippe Brito Goncalves
;
Lavezzo, Marcelo Mendes
;
Nobrega, Priscilla Figueiredo Campos
;
Sakata, Viviane Mayumi
;
Oyamada, Maria Kiyoko
;
Hirata, Carlos Eduardo
;
Yamamoto, Joyce Hisae
Total Authors: 8
|
| Document type: | Journal article |
| Source: | OCULAR IMMUNOLOGY AND INFLAMMATION; v. N/A, p. 7-pg., 2023-01-13. |
| Abstract | |
AimsTo investigate the changes in quality-of-life (QoL) metrics at a 24-month interval in non-acute VKHD patients and their association with inflammation, treatment, and visual function.MethodsSF-36 and VFQ-25 questionnaires were administered at two 24-month-apart moments to 22 non-acute VKHD patients followed for >= 12 months since acute disease onset. "Improvement," "unchanged," or "worsening" in questionnaires scores (difference >5-point) between M1 and M2 and their associations were sought.ResultsAbsence of systemic treatment or optic disc hyperfluorescence was associated with improved general health (SF-36). Improvement in binocular contrast sensitivity resulted in better ocular pain score; absence of anterior uveitis relapse, stable fundus findings, no use of cyclosporine or no intravitreal injections resulted in unchanged/better dependency score; no intravitreal injections resulted in unchanged/better mental health score (VFQ-25).ConclusionStability/improvement in QoL scores was associated with controlled inflammation, better visual function, and no need for treatment. Subclinical inflammatory signs did not impact QoL scores. (AU) | |
| FAPESP's process: | 11/50936-7 - Vogt-Koyanagi-Harada disease: parameters for effective treatment in the acute phase and in long-standing disease |
| Grantee: | Joyce Hisae Yamamoto Takiuti |
| Support Opportunities: | Regular Research Grants |