Mesoporous silica nanoparticles incorporated with Ir(III) complexes: From photophysics to photodynamic therapy

Author(s)

Estevao, Bianca M. ; Vilela, Raquel R. C. ; Geremias, Isabella P. ; Zanoni, Kassio P. S. ; de Camargo, Andrea S. S. ; Zucolotto, Valtencir

• Document type: Journal article
• Source: Photodiagnosis and Photodynamic Therapy; v. 40, p. 9-pg., 2022-10-01.

Abstract

Organically modified mesoporous silica nanoparticles (MSNs) containing Ir complexes (Ir1, Ir2 and Ir3) were successfully synthesized. These Ir-entrapped MCM41-COOH nanoparticles have shown relevant photophysical characteristics including high efficiency in the photoproduction and delivery of singlet oxygen (1O2), which is particularly promising for photodynamic therapy (PDT) applications. In vitro tests have evidenced that complex@MCM41-COOH are able to reduce cell proliferation after 10 min of blue-light irradiation in Hep-G2 liver cancer cells. (AU)

• FAPESP's process: 13/07793-6 - CEPIV - Center for Teaching, Research and Innovation in Glass
• Grantee: Edgar Dutra Zanotto
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 20/05627-5 - Host guest hybrid materials and nanostructured supramolecular systems for photonic and biophotonic applications
• Grantee: Andrea Simone Stucchi de Camargo Alvarez Bernardez
• Support Opportunities: Regular Research Grants
• FAPESP's process: 20/00124-5 - Functionalization of nanomaterials for cancer therapy
• Grantee: Valtencir Zucolotto
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/22056-9 - Nanosystems containing proton "sponge"/gold nanoparticles for tumor hypoxia conditions
• Grantee: Bianca Martins Estevão
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 16/07706-4 - Nanocrystalline luminescent materials: new chemical concepts for energy conversion and sustainability
• Grantee: Kassio Papi da Silva Zanoni
• Support Opportunities: Scholarships in Brazil - Post-Doctoral