Functionalization of nanomaterials for cancer therapy

• Grant number: 20/00124-5
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2021
• End date: January 31, 2023
• Field of knowledge: Physical Sciences and Mathematics - Physics - Condensed Matter Physics
• Principal Investigator: Valtencir Zucolotto
• Grantee: Valtencir Zucolotto
• Host Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Associated researchers: Wagner José Fávaro

Abstract

Recent advances in nanoscience and nanotechnology have expanded our ability to develop multifunctional nanostructures that combine therapeutic and diagnostic functions into a single nanostructured complex. These materials, called "teranostics", have been interesting for many applications, especially in the early diagnosis and treatment of diseases, including cancer. The versatility of these nanomaterial-based structures stems from the possibility of incorporating various types of molecules into the surface of a single nanoparticle, making them perform multiple functions. This research project aims at investigating the interaction of new nanostructured materials composed of spherical nanoparticles or nanorods- with normal and cancer cells, or with reconstituted cell membranes. The incorporation of specific antitumor or antigen structures in the nanosystems will also be carried out, allowing them to target specific cells. Emphasis will be given to understanding the interaction between these compounds and cells and / or cell membranes by spectroscopic, microscopic and calorimetry techniques, aiming at obtaining systems with high stability and well defined properties that are required for nanomedicine applications. These nanoconjugates will be further evaluated for their in vitro toxicity as well as their specificity and interaction with different tumor and normal cell types. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ESTEVAO, BIANCA MARTINS; COMPARETTI, EDSON JOSE; RISSI, NATHALIA CRISTINA; ZUCOLOTTO, VALTENCIR. Anti-GPC1-modified mesoporous silica nanoparticles as nanocarriers for combination therapy and targeting of PANC-1 cells. MATERIALS ADVANCES, v. 2, n. 15, JUN 2021. (18/12670-4, 17/22056-9, 20/00124-5)

RISSI, NATHALIA CRISTINA; COMPARETTI, EDSON J.; ESTEVAO, BIANCA MARTINS; MASTELARO, VALMOR ROBERTO; ZUCOLOTTO, VALTENCIR. Doped Plasmonic Zinc Oxide Nanoparticles with Near-Infrared Absorption for Antitumor Activity. ACS APPLIED NANO MATERIALS, v. 4, n. 9, p. 9779-9789, SEP 24 2021. (18/12670-4, 17/22056-9, 20/00124-5)

ANTONIO, LUANA CORSI; RIBOVSKI, LAIS; PINCELA LINS, PAULA MARIA; ZUCOLOTTO, VALTENCIR. The amount of dextran in PLGA nanocarriers modulates protein corona and promotes cell membrane damage. JOURNAL OF MATERIALS CHEMISTRY B, v. 10, n. 40, p. 13-pg., 2022-09-01. (20/02386-7, 20/00124-5, 17/21869-6, 09/54216-9)

COMPARETTI, EDSON J.; LINS, PAULA M. P.; QUITIBA, JOAO; ZUCOLOTTO, VALTENCIR. Cancer cell membrane-derived nanoparticles block the expression of immune checkpoint proteins on cancer cells and coordinate modulatory activity on immunosuppressive macrophages. Journal of Biomedical Materials Research Part A, v. 110, n. 8, p. 13-pg., 2022-04-05. (18/12670-4, 20/00124-5, 14/50947-7)

FERREIRA, NATALIA NORONHA; MIRANDA, RENATA RANK; MORENO, NATALIA SANCHEZ; LINS, PAULA MARIA PINCELA; LEITE, CELISNOLIA MORAIS; LEITE, ANA ELISA TOGNOLI; MACHADO, THALES RAFAEL; CATALDI, THAIS REGIANI; LABATE, CARLOS ALBERTO; REIS, RUI MANUEL; et al. Using design of experiments (DoE) to optimize performance and stability of biomimetic cell membrane-coated nanostructures for cancer therapy. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, v. 11, p. 16-pg., 2023-02-02. (20/00124-5, 19/25645-0)

COMPARETTI, EDSON J.; FERREIRA, NATALIA N.; FERREIRA, LEONARDO M. B.; KANENO, RAMON; ZUCOLOTTO, VALTENCIR. Immunomodulatory properties of nanostructured systems for cancer therapy. Journal of Biomedical Materials Research Part A, v. 110, n. 5, p. 16-pg., 2022-01-19. (18/12670-4, 19/25645-0, 20/00124-5)

ESTEVAO, BIANCA M.; VILELA, RAQUEL R. C.; GEREMIAS, ISABELLA P.; ZANONI, KASSIO P. S.; DE CAMARGO, ANDREA S. S.; ZUCOLOTTO, VALTENCIR. Mesoporous silica nanoparticles incorporated with Ir(III) complexes: From photophysics to photodynamic therapy. Photodiagnosis and Photodynamic Therapy, v. 40, p. 9-pg., 2022-10-01. (13/07793-6, 20/05627-5, 20/00124-5, 17/22056-9, 16/07706-4)