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Bias Assessment in Medical Imaging Analysis: A Case Study on Retinal OCT Image Classification

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Author(s):
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Oliveira, Gabriel ; David, Lucas ; Padilha, Rafael ; da Silva, Ana Paula ; de Paula, Francine ; Infante, Lucas ; Jorge, Lucio ; Xavier, Patricia ; Dias, Zanoni ; Rocha, AP ; Steels, L ; VandenHerik, J
Total Authors: 12
Document type: Journal article
Source: ICAART: PROCEEDINGS OF THE 14TH INTERNATIONAL CONFERENCE ON AGENTS AND ARTIFICIAL INTELLIGENCE - VOL 3; v. N/A, p. 7-pg., 2022-01-01.
Abstract

Deep learning classifiers can achieve high accuracy in many medical imaging analysis problems. However, when evaluating images from outside the training distribution - e.g., from new patients or generated by different medical equipment - their performance is often hindered, highlighting that they might have learned specific characteristics and biases of the training set and can not generalize to real-world scenarios. In this work, we discuss how Transfer Learning, the standard training technique employed in most visual medical tasks in the literature, coupled with small and poorly collected datasets, can induce the model to capture such biases and data collection artifacts. We use the classification of eye diseases from retinal OCT images as the backdrop for our discussion, evaluating several well-established convolutional neural network architectures for this problem. Our experiments showed that models can achieve high accuracy in this problem, yet when we interpret their decisions and learned features, they often pay attention to regions of the images unrelated to diseases. (AU)

FAPESP's process: 17/12646-3 - Déjà vu: feature-space-time coherence from heterogeneous data for media integrity analytics and interpretation of events
Grantee:Anderson de Rezende Rocha
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 15/11937-9 - Investigation of hard problems from the algorithmic and structural stand points
Grantee:Flávio Keidi Miyazawa
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 17/21957-2 - Learning Visual Clues of the Passage of Time
Grantee:Rafael Soares Padilha
Support Opportunities: Scholarships in Brazil - Doctorate