Development and Characterization of Fully Hydrogenated Soybean Oil and High Oleic Sunflower Oil beta-carotene Loaded Nanostructured Lipid Carriers

Author(s)

Ludtke, Fernanda Luisa ; Grimaldi, Renato ; Cardoso, Lisandro Pavie ; Gigante, Mirna Lucia ; Vicente, Antonio Augusto ; Ribeiro, Ana Paula Badan

• Document type: Journal article
• Source: FOOD BIOPHYSICS; v. N/A, p. 15-pg., 2023-02-07.

Abstract

Nanostructured lipid carriers (NLC) have shown great potential as a delivery system for lipophilic bioactive compounds as they provide protection, high water dispersibility, chemical stability, and oral bioavailability. The less compact crystal structure created by high- and low-melting-point lipids has more space for the entrapment of bioactive compounds, such as beta-carotene, the carotenoid with the highest provitamin A activity. The objective of this study was to produce and characterise beta-carotene-loaded NLC. The study assessed the physical and crystallization properties, entrapment efficiency (EE), and loading capacity (LC) of NLC produced with fully hydrogenated soybean oil and high oleic sunflower oil as high- and low-melting-point lipid matrices, respectively, and soy lecithin, Tween 80, and whey protein isolate (WPI) as emulsifiers. WPI promoted the production of NLC with larger particle size, lower physical stability, and lower IE and LC, compared with other emulsifiers. The melting range of the resulting NLC was within a suitable range for incorporation in foods, with a peak melting temperature above body temperature. (AU)

• FAPESP's process: 16/11261-8 - OILS, FATS AND NANOTECHNOLOGY:DEVELOPMENT OF SOLID LIPID NANOPARTICLES AND NANOSTRUCTURED LIPID CARRIERS FOR INCORPORTATION OF BIOACTIVE LIPOPHILIC COMPOUNDS
• Grantee: Ana Paula Badan Ribeiro
• Support Opportunities: Regular Research Grants
• FAPESP's process: 19/05176-6 - Evaluation of in vitro digestibility of nanostructured lipid carriers containing ²-carotene
• Grantee: Fernanda Luisa Lüdtke
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 19/27354-3 - Architecture of colloidal delivery systems: what is the role of structure on the digestibility?
• Grantee: Rosiane Lopes da Cunha
• Support Opportunities: Research Projects - Thematic Grants