| Full text | |
| Author(s): |
Scariot, Pedro Paulo Menezes
;
Papoti, Marcelo
;
Polisel, Emanuel Elias Camolese
;
Orsi, Juan Bordon
;
Ginkel, Paul R. Van
;
Prolla, Tomas A.
;
Manchado-Gobatto, Fulvia Barros
;
Gobatto, Claudio Alexandre
Total Authors: 8
|
| Document type: | Journal article |
| Source: | Life Sciences; v. 317, p. 17-pg., 2023-02-01. |
| Abstract | |
There is a scarcity of data regarding the acclimation to high altitude (hypoxic environment) accompanied by training at low altitude (normoxic conditions), the so-called "living high-training low" (LHTL) model in rodents. We aimed to investigate the effects of aerobic training on C57BL/6J mice living in normoxic (NOR) or hypoxic (HYP) environments on several parameters, including critical velocity (CV), a parameter regarded as a measure of aerobic capacity, on monocarboxylate transporters (MCTs) in muscles and hypothalamus, as well as on he-matological parameters and body temperature. In each environment, mice were divided into non-trained (N) and trained (T). Forty rodents were distributed into the following experimental groups (N-NOR; T-NOR; N-HYP and T-HYP). HYP groups were in a normobaric tent where oxygen-depleted air was pumped from a hypoxia generator set an inspired oxygen fraction [FiO2] of 14.5 %. The HYP-groups were kept (18 h per day) in a normobaric tent for consecutive 8-weeks. Training sessions were conducted in normoxic conditions ([FiO2] = 19.5 %), 5 times per week (40 min per session) at intensity equivalent to 80 % of CV. In summary, eight weeks of LHTL did not promote a greater improvement in the CV, protein expression of MCTs in different tissues when compared to the application of training alone. The LHTL model increased red blood cells count, but reduced hemoglobin per erythrocyte was found in mice exposed to LHTL. Although the LHTL did not have a major effect on thermo-graphic records, exercise-induced hyperthermia (in the head) was attenuated in HYP groups when compared to NOR groups. (AU) | |
| FAPESP's process: | 17/10201-4 - Effects of aerobic physical training and the availability of wide space housing on the spontaneous physical activity, central and peripheral metabolic and molecular responses |
| Grantee: | Claudio Alexandre Gobatto |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/00272-6 - Effects of caloric restriction mediated by SIRT3 in the aerobic and anaerobic capacities of mice: relations with the spontaneous activity, metabolic parameters and muscle mitochondrial function in aging process |
| Grantee: | Fúlvia de Barros Manchado Gobatto |
| Support Opportunities: | Scholarships abroad - Research |
| FAPESP's process: | 15/01362-9 - Effects of age, caloric restriction diet (Cr) and SIRT3 on spontaneous activity, behavior and oxidative mediators (NO, NOS and orexin) and hypothalamic mitochondrial respiration |
| Grantee: | Claudio Alexandre Gobatto |
| Support Opportunities: | Scholarships abroad - Research |
| FAPESP's process: | 19/05115-7 - Effects of aerobic training and the hypoxic environment on molecular responses related to anaerobic and aerobic metabolism and acid-base properties in the hypothalamus and skeletal muscle of mice |
| Grantee: | Pedro Paulo Menezes Scariot |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 16/12781-5 - Metabolic, hematologic and neuromuscular adaptations from training from "sleep high and train low", followed by taper period: A and randomized double-blind study. |
| Grantee: | Marcelo Papoti |
| Support Opportunities: | Regular Research Grants |