Experimental animal models for denture stomatitis: A methodological review

Author(s)

Moraes, Gustavo S. ; Albach, Thais ; Sugio, Carolina Y. C. ; de Oliveira, Fabio B. ; Neppelenbroek, Karin H. ; Urban, Vanessa M.

• Document type: Journal article
• Source: LABORATORY ANIMALS; v. 56, n. 4, p. 13-pg., 2022-01-24.

Abstract

Denture stomatitis is the most prevalent form of oral candidiasis and the most frequent oral lesion in removable prosthesis wearers. It is characterized by an inflammatory response of the denture-bearing mucosa, especially the palatal mucosa, and its clinical signs include chronic edema and erythema, and papillary hyperplasia. Despite having a multifactorial etiology, its main etiological agent is the infection by Candida albicans. Given its high treatment failure rates, an in vivo model of denture stomatitis should be established to test alternative treatments. The aim of this study is to review the existing denture stomatitis models and to provide an overview of the main methodological differences between them. Over the last 40 years, different animal models were developed in order to study denture stomatitis etiopathogenesis and to assess novel therapies. Many approaches, including the use of antibiotics and immunosuppressors, have to be further investigated in order to establish which protocol is more appropriate and effective for the development of an animal model of denture stomatitis. (AU)

• FAPESP's process: 17/07314-1 - Clinical evaluation of antifungal addition to temporary soft liner in the treatment of denture stomatitis
• Grantee: Karin Hermana Neppelenbroek
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/22996-1 - Tissue response in animal model of tissue conditioner containing inclusion complex antifungal:²-cyclodextrin for denture stomatitis treatment
• Grantee: Carolina Yoshi Campos Sugio
• Support Opportunities: Scholarships in Brazil - Master