| Full text | |
| Author(s): Show less - |
Franca, Tauani Caroline Santos
;
Ribeiro, Ana Julia
;
Mariano, Luisa Natalia Bolda
;
dos Santos, Ana Caroline
;
Venzon, Larissa
;
Somensi, Lincon Bordignon
;
Nunes, Ruan Kaio Silva
;
Cazarin, Camila Andre
;
Okubo, Karen Luz
;
Poerner, Helenita Priscila
;
Bastos, Jairo Kneupp
;
de Souza, Marcia Maria
;
da Silva, Luisa Mota
Total Authors: 13
|
| Document type: | Journal article |
| Source: | Evidence-based Complementary and Alternative Medicine; v. 2022, p. 14-pg., 2022-03-07. |
| Abstract | |
The hydroalcoholic extract of B. dracunculifolia (HEBD) and its major compound p-coumaric acid were evaluated against the severity of intestinal inflammation and behavioral changes like depressive and anxious behavior in colitis mice. Colitis was induced in Swiss mice by oral dextran sulfate sodium (DSS) administration for five days. The mice received vehicle (10 ml/kg), HEBD (3, 30, or 300 mg/kg), or p-coumaric acid (15 mg/kg) orally, once a day for twelve days. Behavioral tests were performed on the 11(th) and 12(th) days after the beginning of the treatments. Moreover, the colon, cortex, and hippocampus were collected to analyze oxidative and inflammatory parameters. The treatment with HEBD (300 mg/Kg), but not p-coumaric acid, showed decreased disease activity index (DAI) values compared to the vehicle group and partially preserved the villi architecture and mucin levels. Furthermore, the HEBD increased the antioxidant defenses in the colon and hippocampus and reduced the myeloperoxidase activity and IL-6 levels in the colon from colitis mice. Colitis mice treated with HEBD did not show depressive-like behavior in the tail suspension test. HEBD reduced colon inflammation, while it maintains antioxidant defenses and mucin levels in this tissue. It may reduce neuropsychiatric comorbidities associated with colitis through its antioxidant effects. (AU) | |
| FAPESP's process: | 17/04138-8 - Attainment of chemical, analytical, biological, pharmacological and technological studies to fill the gaps on the development of Brazilian propolis sector |
| Grantee: | Jairo Kenupp Bastos |
| Support Opportunities: | Research Projects - Thematic Grants |