Effects of photobiomodulation in experimental spinal cord injury models: A systematic review

Author(s)

Tobelem, Daysi da Cruz ; Silva, Tamiris ; Araujo, Tamires ; Andreo, Lucas ; dos Santos Malavazzi, Taina Caroline ; Ratto Tempestini Horliana, Anna Carolina ; Santos Fernandes, Kristianne Porta ; Bussadori, Sandra Kalil ; Mesquita-Ferrari, Raquel Agnelli

• Document type: Journal article
• Source: Journal of Biophotonics; v. 15, n. 8, p. 14-pg., 2022-05-19.

Abstract

This systematic review investigated the repercussions of photobiomodulation using low-level laser therapy (LLLT) for the treatment of spinal cord injury (SCI) in experimental models. Studies were identified from relevant databases published between January 2009 and December 2021. Nineteen original articles were selected and 68.4% used light at an infrared wavelength. There was a considerable variation of the power used (from 25 to 200 mW), total application time (8-3000 s) and total energy (0.3-450 J). In 79% of the studies, irradiation was initiated immediately after or within 2 h of the SCI, and treatment time ranged continuously from 5 to 21 days. In conclusion, LLLT can be an auxiliary therapy in the treatment of SCI, playing a neuroprotective role, enabling functional recovery, increasing the concentration of nerve connections around the injury site and reducing pro-inflammatory cytokines. However, there is a need for standardization in the dosimetric parameters. (AU)

• FAPESP's process: 20/13976-0 - Evaluation of the effects of vascular systemic photobiomodulation on the inflammatory process and the morphological aspects of skeletal muscle during the repair process after acute injury
• Grantee: Raquel Agnelli Mesquita Ferrari
• Support Opportunities: Regular Research Grants