Combinatorial effect of pH and ionic strength in the release of charged dyes from silk fibroin membranes

Author(s)

Bertolini Neto, Jose Armando ; dos Reis, Luisa Storelli ; Tomoda, Bruno Thorihara ; de Moraes, Mariana Agostini

• Document type: Journal article
• Source: MRS COMMUNICATIONS; v. 12, n. 4, p. 6-pg., 2022-06-29.

Abstract

The aim of this work was to prepare silk fibroin (SF) membranes incorporated with cationic and anionic dyes, in order to analyze the behavior of SF matrix loaded with charged compounds. For that, the combinatorial effect of pH and ionic strength on the release kinetics was assessed, showing that cationic dye has poor interaction with SF and high release rate, whereas anionic dye presented strong hydrophobic interactions with SF, being retained within the matrix. These results help elucidate the behavior of SF in the presence of charged dyes, which can be outspread for the release of charged drugs. (AU)

• FAPESP's process: 16/17555-3 - MEMBRANES OF NATURAL POLYMERS WITH ACTIVE COMPOUNDS FOR APPLICATION AS HIGH PERFORMANCE WOUND DRESSINGS
• Grantee: Mariana Agostini de Moraes
• Support Opportunities: Regular Research Grants