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Development of microstructured materials using biopolymer for high performance dressings

Grant number: 13/18958-6
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2014
Effective date (End): December 31, 2016
Field of knowledge:Engineering - Chemical Engineering
Principal Investigator:Marisa Masumi Beppu
Grantee:Giovana Maria Genevro
Home Institution: Faculdade de Engenharia Química (FEQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


The recovery of chronic wounds, that present complications and require high time for healing, is still a challenge to medicine because usually is an expensive process and in some cases result in amputation of the injured limb. The development of dressings which combine all requirements, such as maintenance of the wound surface moist as well as removal of excess exudate and protection of secondary infections in the wound is a current topic. In this work, we will combine the properties of three natural polymers that play an important role in the field of biomaterials, such as the antimicrobial activity of chitosan, the elasticity of glucomannan and the mechanical strength of silk fibroin in order to obtain a material with high moisture content , resistant and flexible, that has low cost and is environmentally friendly. From the technological point of view, we aim to obtain asymmetric membranes with a dense top face to control the water loss and the passage of microorganisms and a porous face for contact with the wound surface, used to absorb and drain excess exudate and maintain moisture. From the scientific point of view, we will study the thermodynamic behavior, the interactions between these polymers, as well as the parameters that influence the pores formation and how it affect the mechanical properties, the permeability to water vapor, the antimicrobial activity and the biocompatibility. It is expected at the end of this study, to learn the fundamental knowledge of the combination of these three natural polymers as well as to prepare a functional material, with high quality, good performance and low cost, also fulfilling an important social function.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GENEVRO, GIOVANA MARIA; DE MORAES, MARIANA AGOSTINI; BEPPU, MARISA MASUMI. Freezing influence on physical properties of glucomannan hydrogels. International Journal of Biological Macromolecules, v. 128, p. 401-405, MAY 1 2019. Web of Science Citations: 1.
GENEVRO, GIOVANA MARIA; GOMES NETO, REGINALDO JOSE; BEPPU, MARISA NLASUMI; DE MORAES, MARIANA AGOSTINI; PAULO, LETICIA DE ALMEIDA; LOPES, PATRICIA SANTOS. Glucomannan asymmetric membranes for wound dressing. Journal of Materials Research, v. 34, n. 4, p. 481-489, FEB 28 2019. Web of Science Citations: 2.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
GENEVRO, Giovana Maria. Development of microestructured materials using biopolymers for high performance dressings. 2017. Doctoral Thesis - Universidade Estadual de Campinas, Faculdade de Engenharia Química.

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Filed patent(s) as a result of this research project

PROCESSO DE OBTENÇÃO DE MEMBRANAS ASSIMÉTRICAS, MEMBRANAS ASSIM OBTIDAS E USO BR1020150319339 - Universidade Estadual de Campinas (UNICAMP) . Giovana Maria Genevro; Reginaldo José Gomes Neto; Mariana Agostini De Moraes; Marisa Masumi Beppu - December 2015, 18

Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação PCT/BR2016/000130 - Universidade Estadual de Campinas (UNICAMP) . Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação - November 2016, 18