Development of microstructured materials using biopolymer for high performance dressings

• Grant number: 13/18958-6
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: January 01, 2014
• End date: December 31, 2016
• Field of knowledge: Engineering - Chemical Engineering
• Principal Investigator: Marisa Masumi Beppu
• Grantee: Giovana Maria Genevro
• Host Institution: Faculdade de Engenharia Química (FEQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The recovery of chronic wounds, that present complications and require high time for healing, is still a challenge to medicine because usually is an expensive process and in some cases result in amputation of the injured limb. The development of dressings which combine all requirements, such as maintenance of the wound surface moist as well as removal of excess exudate and protection of secondary infections in the wound is a current topic. In this work, we will combine the properties of three natural polymers that play an important role in the field of biomaterials, such as the antimicrobial activity of chitosan, the elasticity of glucomannan and the mechanical strength of silk fibroin in order to obtain a material with high moisture content , resistant and flexible, that has low cost and is environmentally friendly. From the technological point of view, we aim to obtain asymmetric membranes with a dense top face to control the water loss and the passage of microorganisms and a porous face for contact with the wound surface, used to absorb and drain excess exudate and maintain moisture. From the scientific point of view, we will study the thermodynamic behavior, the interactions between these polymers, as well as the parameters that influence the pores formation and how it affect the mechanical properties, the permeability to water vapor, the antimicrobial activity and the biocompatibility. It is expected at the end of this study, to learn the fundamental knowledge of the combination of these three natural polymers as well as to prepare a functional material, with high quality, good performance and low cost, also fulfilling an important social function.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GENEVRO, GIOVANA MARIA; GOMES NETO, REGINALDO JOSE; BEPPU, MARISA NLASUMI; DE MORAES, MARIANA AGOSTINI; PAULO, LETICIA DE ALMEIDA; LOPES, PATRICIA SANTOS. Glucomannan asymmetric membranes for wound dressing. Journal of Materials Research, v. 34, n. 4, p. 481-489, FEB 28 2019. (13/18958-6)

GENEVRO, GIOVANA MARIA; DE MORAES, MARIANA AGOSTINI; BEPPU, MARISA MASUMI. Freezing influence on physical properties of glucomannan hydrogels. International Journal of Biological Macromolecules, v. 128, p. 401-405, MAY 1 2019. (13/18958-6)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

GENEVRO, Giovana Maria. Development of microestructured materials using biopolymers for high performance dressings. 2017. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Engenharia Química Campinas, SP.