Tumor microenvironment in salivary gland carcinomas: An orchestrated state of chaos

Author(s)

Abu Egal, Erika Said ; Scarini, Joao Figueira ; de Lima-Souza, Reydson Alcides ; Lavareze, Luccas ; Fernandes, Patricia Maria ; Emerick, Carolina ; Goncalves, Mayara Trevizol ; Helms, My N. ; Altemani, Albina ; Mariano, Fernanda Viviane

• Document type: Journal article
• Source: Oral Oncology; v. 127, p. 11-pg., 2022-02-18.

Abstract

Salivary gland carcinomas (SGC) are rare tumors of heterogeneous morphology and many histological subtypes. Like other tumors, the SGC mass consists of a varied population of malignant cells and a diverse array of immune cells, cancer-associated fibroblasts, cytokines, chemokines, extracellular matrix proteins, and metalloproteinases, collectively known as the tumor microenvironment (TME). This chaotic network serves as an important physical mediator of cancer cell growth. In this review, we provided current insights into the TME of some of the most common SGC. Here, we highlighted the histological heterogeneity of these tumors, delineated the nature/intensity of inflammatory infiltrates, and the mechanisms involved in immunological escaping related to each SGC subtype. (AU)

• FAPESP's process: 17/00831-0 - Study of genetic and metabolic changes of pleomorphic adenoma and carcinoma ex pleomorphic adenoma by exome, gene expression and immunohistochemistry
• Grantee: Fernanda Viviane Mariano Brum Corrêa
• Support Opportunities: Scholarships in Brazil - Young Researchers
• FAPESP's process: 19/09419-0 - Genomic alterations in the malignant transformation of the Pleomorphic Adenoma
• Grantee: João Figueira Scarini
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 17/13167-1 - Study of metabolic changes of pleomorphic adenoma and carcinoma ex pleomorphic adenoma by immuno-histochemistry
• Grantee: Larissa Fernandes Rosa
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 19/06809-2 - Analysis of mass spectrometry in the malignant transformation of the pleomorphic adenoma. correlation of data with gene expression and exome
• Grantee: Reydson Alcides de Lima Souza
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 15/07304-0 - Study of genetic and metabolic changes of pleomorphic adenoma and carcinoma ex pleomorphic adenoma by exome, gene expression and immunohistochemistry
• Grantee: Fernanda Viviane Mariano Brum Corrêa
• Support Opportunities: Research Grants - Young Investigators Grants