Lateralization in Hemiparkinsonian Rats Is Affected by either Deep Brain Stimulation or Glutamatergic Neurotransmission in the Inferior Colliculus

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Melo-Thomas, Liana ; Tacken, Lars ; Richter, Nicole ; de Almeida, Davina ; Raposo, Catarina ; de Melo, Silvana Regina ; Thomas, Uwe ; de Paiva, Yara Bezerra ; Medeiros, Priscila ; Coimbra, Norberto Cysne ; Schwarting, Rainer

• Document type: Journal article
• Source: ENEURO; v. 9, n. 4, p. 19-pg., 2022-07-01.

Abstract

After unilateral lesion of the medial forebrain bundle by 6-OHDA rats exhibit lateralized deficits in spontaneous behavior or apomorphine-induced rotations. We investigated whether such lateralization is attenuated by either deep brain stimulation (DBS) or glutamatergic neurotransmission in the inferior colliculus (IC) of Wistar rats. Intracollicular DBS did not affect spontaneous lateralization but attenuated apomorphine-induced rotations. Spontaneous lateralization disappeared after either the glutamatergic antagonist MK-801 or the agonist NMDA microinjections into the IC. Apomorphine-induced rotations were potentiated by MK-801 but were not affected by NMDA intracollicular microinjection. After injecting a bidirectional neural tract tracer into the IC, cell bodies and/or axonal fibers were found in the periaqueductal gray matter, superior colliculus, substantia nigra, cuneiform nucleus, and pedunculo-pontine tegmental nucleus, suggesting the involvement of these structures in the motor improvement after IC manipulation. Importantly, the side of the IC microinjection regarding the lesion (ipsilateral or contralateral) is particularly important, and this effect may not involve the neostriatum directly. (AU)

• FAPESP's process: 17/19799-0 - Effects of sildenafil (Viagra, Pfizer) on the inflammatory profile of Parkinson's Disease
• Grantee: Davi Felipe de Almeida
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 19/11448-9 - Induction of the Parkinson's Disease model by 6-ohda (6-hydroxydopamine) and behavioral analysis
• Grantee: Davi Felipe de Almeida
• Support Opportunities: Scholarships abroad - Research Internship - Scientific Initiation
• FAPESP's process: 20/15050-7 - Study of the role played by endocannabinoid and endovaniloid signalling in the pallidum on the activity of the neostriatum-pallido-nigral disinhibitory and nigro-tectal inhibitory pathways during the organization of innate fear of animals confronted to snakes
• Grantee: Norberto Cysne Coimbra
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/04194-0 - Identification of new molecules with chemotherapeutic effect in human glioma and characterization of the mechanism
• Grantee: Catarina Raposo Dias Carneiro
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 17/13560-5 - Effect of deep brain stimulation and cannabidiol treatment in the subthalamic nucleus on the motors and non-Motors symptoms in the experimental model of Parkinson Disease
• Grantee: Priscila Medeiros de Freitas
• Support Opportunities: Scholarships in Brazil - Post-Doctoral