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Long-term effects of COVID-19 in diabetic and non-diabetic patients

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Author(s):
Alberca, Ricardo Wesley ; Ramos, Yasmim Alefe Leuzzi ; Pereira, Natalli Zanete ; Beserra, Danielle Rosa ; Branco, Anna Claudia Calvielli Castelo ; Orfali, Raquel Leao ; Aoki, Valeria ; Duarte, Alberto Jose da Silva ; Sato, Maria Notomi
Total Authors: 9
Document type: Journal article
Source: FRONTIERS IN PUBLIC HEALTH; v. 10, p. 5-pg., 2022-08-15.
Abstract

The literature presents several reports of the impact of glycemic control and diabetes in the inflammatory and coagulatory response during coronavirus disease 2019 (COVID-19). Nevertheless, the long-term impact of the COVID-19 in diabetic patients is still to be explored. Therefore, we recruited 128 patients and performed a longitudinal analysis on COVID-19-associated biomarkers of patients with COVID-19, tree and 6 months after COVID-19 recovery and put into perspective the possible long-term complication generated after COVID-19. In our investigation, we failed to verify any long-term modification on inflammatory biomarkers, but detected an increase in the glycemia and glycated hemoglobin in patients without any pre-existing history or diagnosis of diabetes (non-diabetic patients). Although diabetic and non-diabetic patients presented elevated levels of glycated hemoglobin, the c-peptide test indicated a normal beta cell function in all patients. (AU)

FAPESP's process: 20/13148-0 - Evaluation of ATP-adenosine axis in lymphocytes in SARS-CoV-2 infection
Grantee:Maria Notomi Sato
Support Opportunities: Regular Research Grants
FAPESP's process: 19/02679-7 - Effect of maternal and paternal supplementation with antioxidant in pulmonary inflammatory process of the offspring of mice
Grantee:Ricardo Wesley Alberca Custódio
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 19/25119-7 - Maternal-fetal interface: immunopathogenesis and vaccinal intervention in viral infections
Grantee:Maria Notomi Sato
Support Opportunities: Research Projects - Thematic Grants