Solubility of aspirin, ketoprofen and R-(-)-carvone in supercritical CO2 in binary, ternary and quaternary systems: Effect of co-solutes

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Author(s):	Dujarric, Katia ; Coutinho, Isabela Trindade ; Mantuaneli, Glaucia Toth ; Tassaing, Thierry ; Champeau, Mathilde Total Authors: 5
Document type:	Journal article
Source:	JOURNAL OF SUPERCRITICAL FLUIDS; v. 189, p. 11-pg., 2022-08-10.
Abstract
To better understand the solubility of multicomponent systems in supercritical CO2, an in situ IR spectrophotometer coupled to a high-pressure cell was used to measure the solubility of aspirin, ketoprofen and carvone in binary, ternary, and quaternary systems at 333.2 K and 353.2 K in pressures between of 5-30 MPa. DSC and ATR-FTIR allowed measuring the melting temperature of the compounds and optical microscopy was used to observe the phases. Aspirin formed a eutectic mixture with ketoprofen and was solubilized in carvone, resulting in an enhancement of its solubility in ternary and quaternary systems. On the contrary, ketoprofen solubility was higher in binary systems, due to a decrease in vapor pressure when in solution. Finally, carvone solubility was increased by the presence of other compounds at 333.2 K and pressures below 9 MPa, whereas at other conditions, the solubility decreased as a result of a decrease in vapor pressure. (AU)

FAPESP's process:	18/23902-3 - Development of a methodology for the optimization of supercritical CO2-assisted impregnation of polymers with natural extracts
Grantee:	Mathilde Julienne Gisele Champeau
Support Opportunities:	Regular Research Grants