| Full text | |
| Author(s): |
Sponton, Carlos H.
;
de Lima-Junior, Jose Carlos
;
Leiria, Luiz O.
Total Authors: 3
|
| Document type: | Journal article |
| Source: | TRENDS IN ENDOCRINOLOGY AND METABOLISM; v. 33, n. 8, p. 13-pg., 2022-07-12. |
| Abstract | |
Owing to its unique capacity to clear macronutrients from circulation and use them to produce heat, thermogenic fat is capable of regulating glucose, lipids, and branched-chain amino acids (BCAA) circulatory levels. At the same time, its activity yields a higher energy expenditure, thereby conferring protection against cardiometabolic diseases. Our knowledge on the mechanisms of uptake and intracellular metabolism of such energy substrates into thermogenic fat has meaningfully evolved in recent years. This has allowed us to better understand how the thermogenic machinery processes those molecules to utilize them as substrates for heating up the body. Here, we discuss recent advances in the molecular and cellular regulatory process that governs the uptake and metabolism of such substrates within thermogenic fat. (AU) | |
| FAPESP's process: | 20/05040-4 - Translational study on the role of specialised pro-resolving lipid mediators in the tolerance against CARS-CoV-2 infection |
| Grantee: | Luiz Osório Silveira Leiria |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 17/08264-8 - Investigation on the mechanisms underlying brown adipose tissue/liver crosstalk for the regulation of hepatic de novo lipogenesis and glucose production |
| Grantee: | Luiz Osório Silveira Leiria |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 19/26008-4 - Adipocyte-secreted lipids as messengers linking insulin resistance to hyperinsulinemia in obesity |
| Grantee: | Luiz Osório Silveira Leiria |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 19/15025-5 - Unveiling the PRDM16 transcriptional complex related to the inhibition of ceramides synthesis genes in adipocytes |
| Grantee: | Carlos Henrique Grossi Sponton |
| Support Opportunities: | Research Grants - Young Investigators Grants |