| Full text | |
| Author(s): |
Martins, Lucas Gelain
;
Fregonesi, Natalia
;
Bazotte, Roberto Barbosa
;
Laguila Visentainer, Jeane Eliete
;
Tasic, Ljubica
Total Authors: 5
|
| Document type: | Journal article |
| Source: | MOLECULAR OMICS; v. 19, n. 1, p. 9-pg., 2022-09-10. |
| Abstract | |
It was demonstrated that effervescent glutamine supplementation in HIV+ individuals treated with antiretroviral therapy (ART) increased CD4+ T lymphocytes, decreased inflammation biomarkers, and brought health benefits. This pilot study aimed to explore serum metabolite variations in the HIV+ group under ART after 30 days of supplementation with glutamine, and in comparison to the matched HIV- group. The group of HIV+ showed lower levels of choline, creatine, pyruvate, glutamate, lysine, and tyrosine when compared to the HIV- group. Glucose, lipids, lactate, glutamine, phenylalanine, threonine, and phenylalanine/tyrosine were higher in HIV+ patients under long ART. Serum metabolome variations were shown to be consistent with the health improvements observed in the HIV+ group after effervescent glutamine supplementation, which might aid in ART in HIV+ individuals. (AU) | |
| FAPESP's process: | 18/24069-3 - ReSEARCH: Recognizing Signatures of the Exposome to Anticipate the Risks for a Continuous Health |
| Grantee: | Fernando Barbosa Júnior |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 18/06510-4 - Application of Nuclear Magnetic Resonance (NMR) in metabolomics and metabonomics of human diseases |
| Grantee: | Ljubica Tasic |
| Support Opportunities: | Regular Research Grants |