Curcumin-Loaded Mesoporous Silica Nanoparticles Dispersed in Thermo-Responsive Hydrogel as Potential Alzheimer Disease Therapy

Author(s)

Ribeiro, Tais de Cassia ; Sabio, Rafael Miguel ; Luiz, Marcela Tavares ; de Souza, Lucas Canto ; Fonseca-Santos, Bruno ; Cides da Silva, Luis Carlos ; de Abreu Fantini, Marcia Carvalho ; Planeta, Cleopatra da Silva ; Chorilli, Marlus

• Document type: Journal article
• Source: PHARMACEUTICS; v. 14, n. 9, p. 19-pg., 2022-09-01.

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive and behavioral impairment. Curcumin-loaded mesoporous silica nanoparticles (MSN-CCM) can overcome the drawbacks related to the free curcumin (CCM) clinical application, such as water insolubility and low bioavailability, besides acting over the main causes associated to AD. A thermo-responsive hydrogel is an interesting approach for facilitating the administration of the nanosystem via a nasal route, as well as for overcoming mucociliary clearance mechanisms. In light of this, MSN-CCM were dispersed in the hydrogel and evaluated through in vitro and in vivo assays. The MSNs and MSN-CCM were successfully characterized by physicochemical analysis and a high value of the CCM encapsulation efficiency (EE%, 87.70 +/- 0.05) was achieved. The designed thermo-responsive hydrogel (HG) was characterized by rheology, texture profile analysis, and ex vivo mucoadhesion, showing excellent mechanical and mucoadhesive properties. Ex vivo permeation studies of MSN-CCM and HG@MSN-CCM showed high permeation values (12.46 +/- 1.08 and 28.40 +/- 1.88 mu g cm(-2) of CCM, respectively) in porcine nasal mucosa. In vivo studies performed in a streptozotocin-induced AD model confirmed that HG@MSN-CCM reverted the cognitive deficit in mice, acting as a potential formulation in the treatment of AD. (AU)

• FAPESP's process: 19/19228-8 - Evaluation of curcumin potential incorporated in mesoporous silica nanoparticles dispersed in thermo-responsive hydrogels in the treatment of Alzheimer's Disease
• Grantee: Tais de Cassia Ribeiro
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 18/25377-3 - Potential evaluation of cetuximab-modified mesoporous silica nanoparticles as docetaxel carrier to prostate cancer treatment.
• Grantee: Rafael Miguel Sábio
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 14/50928-2 - INCT 2014: Pharmaceutical Nanotechnology: a transdisciplinary approach
• Grantee: Maria Vitória Lopes Badra Bentley
• Support Opportunities: Research Projects - Thematic Grants