Use of carbohydrate-directed enzymes for the potential exploitation of sugarcane bagasse to obtain value-added biotechnological products

Author(s):Show less -

Campos Antonieto, Amanda Cristina ; Vieira Nogueira, Karoline Maria ; Mendes, Vanessa ; Maues, David Batista ; Oshiquiri, Leticia Harumi ; Zenaide-Neto, Hermano ; de Paula, Renato Graciano ; Gaffey, James ; Tabatabaei, Meisam ; Gupta, Vijai Kumar ; Silva, Roberto Nascimento

• Document type: Journal article
• Source: International Journal of Biological Macromolecules; v. 221, p. 16-pg., 2022-09-12.

Abstract

Microorganisms, such as fungi and bacteria, are crucial players in the production of enzymatic cocktails for biomass hydrolysis or the bioconversion of plant biomass into products with industrial relevance. The biotechnology industry can exploit lignocellulosic biomass for the production of high-value chemicals. The generation of biotechnological products from lignocellulosic feedstock presents several bottlenecks, including low efficiency of enzymatic hydrolysis, high cost of enzymes, and limitations on microbe metabolic performance. Genetic engineering offers a route for developing improved microbial strains for biotechnological applications in high-value product biosynthesis. Sugarcane bagasse, for example, is an agro-industrial waste that is abundantly produced in sugar and first-generation processing plants. Here, we review the potential conversion of its feed-stock into relevant industrial products via microbial production and discuss the advances that have been made in improving strains for biotechnological applications. (AU)

• FAPESP's process: 21/01580-7 - Characterization and engineering of new transcription factors involved in the stress response during cellulase production by Trichoderma reesei
• Grantee: David Batista Maués
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 19/19569-0 - Functional characterization of the calcium-dependent signaling pathway in the regulation of cellulases expression by the fungus Trichoderma reesei
• Grantee: Letícia Harumi Oshiquiri
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 19/11655-4 - Functional studies of gene regulatory networks in Trichoderma reesei during the cellulases formation
• Grantee: Roberto do Nascimento Silva
• Support Opportunities: Research Projects - Thematic Grants