| Full text | |
| Author(s): |
de Figueiredo, Rebeca Machado
;
Falconi-Sobrinho, Luiz Luciano
;
Andrade Leite-Panissi, Christie Ramos
;
Huston, Joseph P.
;
Mattern, Claudia
;
de Carvalho, Milene Cristina
;
Coimbra, Norberto Cysne
Total Authors: 7
|
| Document type: | Journal article |
| Source: | JOURNAL OF PSYCHOPHARMACOLOGY; v. 36, n. 11, p. 16-pg., 2022-10-14. |
| Abstract | |
Background: Panic-like reactions elicited by electrical stimulation of the dorsal periaqueductal grey matter (ES-dPAG) seem to be regulated by dopamine (DA). We showed that DA applied intranasally (IN) increased escape-behaviour thresholds induced by ES-dPAG of rats, indicating a panicolytic-like effect. Aims: We investigated whether IN-DA increases escape-response thresholds induced by ES-dPAG by acting on D-2-like receptors, and whether IN-DA affects escape responses elicited by the presence of a potential predator and by open space and height of the elevated T-maze (ETM) as well as motor performance in the open field (OF) test. Methods: Wistar rats exposed to ES-dPAG were treated with Sulpiride (SUL, 40 mg/kg, D-2-like receptor antagonist) previously IN-DA (2 mg/kg). Independent groups of rats treated with IN-DA were submitted to prey versus snake paradigm (PSP), ETM and OF. Results: Anti-aversive effects of the IN-DA were reduced by SUL pretreatment in the ES-dPAG test. IN-DA did not affect the escape number in the PSP nor the escape latencies in the ETM as well as motor performance in the OF. Conclusions/interpretation: The IN-DA effects in reducing unconditioned fear responses elicited by ES-dPAG seem to be mediated by D-2-like receptors. The lack of effects on panic-related responses in the ETM and PSP may be related to the possibility of avoiding the danger inherent to these models, a defence strategy not available during ES-dPAG. These findings cannot be attributed to motor performance. The decision-making responses to avoid dangerous situations can be orchestrated by supra-mesencephalic structures connected by non-dopaminergic inputs. (AU) | |
| FAPESP's process: | 17/11855-8 - Study of corpus striatum and ventral mesencephalon endocanabinoid influence on neostriato-nigro-tectal GABAergic pathways during panic reactions of rodents threatened by venomous snakes |
| Grantee: | Norberto Cysne Coimbra |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/10984-8 - Influence of the anterior cingulate cortex and involvement of hypothalamic NMDA and AMPA/kainite glutamatergic receptorsin the organization of the defensive behaviorand innate fear-induced antinociception elaborated by posterior hypothalamus |
| Grantee: | Luiz Luciano Falconi Sobrinho |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 19/05255-3 - Study of the role of glutamatergic pathways from the anterior cingulate cortex on nitrergic mechanisms of the ventromedial hypothalamus and periaqueductal grey matter involved in the genesis of defensive responses evoked in mice threatened by snakes |
| Grantee: | Luiz Luciano Falconi Sobrinho |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 20/15050-7 - Study of the role played by endocannabinoid and endovaniloid signalling in the pallidum on the activity of the neostriatum-pallido-nigral disinhibitory and nigro-tectal inhibitory pathways during the organization of innate fear of animals confronted to snakes |
| Grantee: | Norberto Cysne Coimbra |
| Support Opportunities: | Regular Research Grants |