Roles of cannabinoid CB1 and CB2 receptors in the modulation of psychostimulant responses

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Author(s):	Gobira, P. H. ; Joca, S. R. ; Moreira, F. A. Total Authors: 3
Document type:	Journal article
Source:	ACTA NEUROPSYCHIATRICA; v. N/A, p. 11-pg., 2022-08-22.
Abstract
Addiction to psychostimulant drugs, such as cocaine, D-amphetamine, and methamphetamine, is a public health issue that substantially contributes to the global burden of disease. Psychostimulant drugs promote an increase in dopamine levels within the mesocorticolimbic system, which is central to the rewarding properties of such drugs. Cannabinoid receptors (CB1R and CB2R) are expressed in the main areas of this system and implicated in the neuronal mechanisms underlying the rewarding effect of psychostimulant drugs. Here, we reviewed studies focusing on pharmacological intervention targeting cannabinoid CB1R and CB2R and their interaction in the modulation of psychostimulant responses. (AU)

FAPESP's process:	17/24304-0 - New perspectives in the use of drugs that modify atypical neurotransmitters in the treatment of neuropsychiatric disorders
Grantee:	Francisco Silveira Guimaraes
Support Opportunities:	Research Projects - Thematic Grants


FAPESP's process:	17/19284-0 - Involvement of histone acetylation in modulating vulnerability to the cocaine-effects induced by exposure to cannabinoids during adolescence
Grantee:	Pedro Henrique Gobira Nunes
Support Opportunities:	Scholarships abroad - Research Internship - Post-doctor