Abstract
The need to develop new therapeutic targets for the treatment of neuropsychiatric disorders is a consensus in the scientific literature. Endocannabinoids (eCBs) and nitric oxide (NO) have been proposed as two of these possible targets. Studies from our group have disclosed the therapeutic potential of drugs that interfere with these two atypical neurotransmitters in anxiety, depressive, psychotic disorders, Parkinson's disease, aggressive behavior and neurodegeneration/neurotoxicity. Cannabidiol (CBD), a non-psychotomimetic phytocannabinoid, which, among other effects, can increase the levels of the eCB anandamide, is already undergoing clinical trials to test its efficacy in some of these disorders. However, several important questions still remain related to the therapeutic potential of these drugs in other specific disorders as well as to the mechanisms involved. In the last few years our studies have indicated new possibilities, including facilitation of adult hippocampal neurogenesis and autophagy and the possible involvement of neuroinflammatory/neuroimmune mechanisms. The present project aimed at continuing this research line, trying to investigate 1. Which is the involvement and mechanisms of the anti-inflammatory effects of CBD and drugs that modify the NO and eCB system in their potential therapeutic effects?; 2. Which other neuropsychiatric disorders could benefice from these drugs?; 3. In case of co-morbities such as metabolic syndrome and anxiety disorders, in which an inflammatory component is present, would these new therapies be effective?; 4. Which other intra-cellular pathways would be involved?; 5. Which is the specific eCB involvement in the modulation of rewarding and aversive responses?; 6. Which specific epigenetic mechanisms are involved with these effects? (AU)
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Matéria(s) publicada(s) na Agência FAPESP sobre o auxílio: |
Cannabidiol reduces aggressiveness, study concludes
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Articles published in other media outlets (70 total):
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UOL: Medicamentos que vêm da cannabis são alvo de pesquisa intensa (16/Apr/2020)
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Gazeta do Povo: O que já sabemos sobre o uso terapêutico do canabidiol (31/Aug/2019)
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UOL: Canabidiol diminui agressividade, conclui estudo (22/Jul/2019)
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Portal Exame: Canabidiol diminui agressividade, diz estudo da USP (22/Jul/2019)
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Sechat: Medicamentos que vêm da Cannabis são alvo de pesquisa intensa (17/Apr/2020)
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Central das Notícias: Medicamentos que vêm da cannabis são alvo de pesquisa intensa (16/Apr/2020)
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Scientific Inquirer (EUA): Cannabis appears to reduce aggressiveness, study (09/Sep/2019)
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Santé blog (França): Cannabis : Le cannabidiol pour réduire l'agressivité (06/Sep/2019)
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Paperblog (France): CANNABIS : Le cannabidiol pour réduire l'agressivité (06/Sep/2019)
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Clear Critique: Cannabidiol Attenuates Aggressiveness: Study (05/Sep/2019)
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Santé blog (França): CANNABIS : Le cannabidiol pour réduire l'agressivité (05/Sep/2019)
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The 1ml Store (Reino Unido): Cannabidiol Attenuates Aggressiveness: Study (05/Sep/2019)
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CBD Olie: Cannabidiol vermindert de agressiviteit, concludeert de studi (05/Sep/2019)
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Birnith Mining & Construction (China): Cannabidiol vermindert de agressiviteit, concludeert de studi (05/Sep/2019)
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Gazeta do Povo online: O que já sabemos sobre o uso terapêutico do canabidiol (04/Sep/2019)
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All My Family Care: In test with rats, cannabidiol showed sustained effects against depression for seven days (31/Aug/2019)
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HealthMedicinentral: Cannabidiol reduces aggressiveness, study concludes (26/Aug/2019)
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Dr. Soler Cannabis (Porto Rico): Cannabidiol reduces aggressiveness, study concludes (26/Aug/2019)
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David Icke: Cannabidiol reduces aggressiveness, study concludes (26/Aug/2019)
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Science and Technology Research News (EUA): Cannabidiol Reduces Aggressiveness, Study Concludes (23/Aug/2019)
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Gold Voice: Canabindol reduces aggressiveness, study concludes (12/Aug/2019)
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The Daily Leaf (EUA): Study Shows CBD Reduces Aggressive Behavior (05/Aug/2019)
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Business Standard (Índia) online: Study finds cannabidiol can reduce isolation-induced aggression (04/Aug/2019)
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Sify (Índia): Study finds cannabidiol can reduce isolation-induced aggression (04/Aug/2019)
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Revista Ecociencias (Chile) online: El cannabidiol disminuye la agresividad, de acuerdo con un estudio (01/Aug/2019)
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Genetic Engineering & Biotechnology News (EUA): CBD Mellows Out Aggressive Shut-Ins (31/Jul/2019)
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Nutrition Insight (Holanda): Could CBD reduce aggression? CBD-dosed mice half as likely to attack intruders (31/Jul/2019)
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Global Health News Wire (EUA): Cannabidiol Reduces Aggressiveness, Study Concludes (31/Jul/2019)
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Green Rush Daily: CBD Can Reduce Isolation-Induced Aggression, Study Finds (31/Jul/2019)
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International Business Times (EUA): CBD Compound In Marijuana Can Reduce Aggressiveness Induced By Isolation (30/Jul/2019)
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Medical Xpress (Reino Unido): Cannabidiol reduces aggressiveness, study concludes (30/Jul/2019)
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ScienceBlog: Cannabidiol reduces aggressiveness, study concludes (30/Jul/2019)
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Before It's News (EUA): Cannabidiol Reduces Aggressiveness, Study Concludes (30/Jul/2019)
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Medindia (Índia): Cannabidiol Attenuates Aggressiveness: Study (30/Jul/2019)
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Steemit: Cannabidiol reduces aggressiveness, study concludes (30/Jul/2019)
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Natural Blaze: Cannabidiol Reduces Aggressiveness, Study Concludes (30/Jul/2019)
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ScienceBeta: Cannabidiol Mitigates Isolation-Induced Aggression (30/Jul/2019)
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W3 live news (Austrália): Cannabidiol Reduces Aggressiveness, Study Concludes (30/Jul/2019)
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Tech Deeps: Cannabidiol Reduces Aggressiveness, Study Concludes (30/Jul/2019)
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GDS Noticias (Argentina): Cannabidiol Reduces Aggressiveness, Study Concludes (30/Jul/2019)
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Busy.org: Cannabidiol Reduces Aggressiveness, Study Concludes (30/Jul/2019)
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SteemPeak: Cannabidiol Reduces Aggressiveness, Study Concludes (30/Jul/2019)
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New Republic Liberia (Libéria): Cannabidiol Reduces Aggressiveness, Study Concludes (30/Jul/2019)
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Science Codex: Cannabidiol reduces aggressiveness, study concludes (29/Jul/2019)
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Scienmag Science Magazine (Reino Unido): Cannabidiol reduces aggressiveness, study concludes (29/Jul/2019)
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Neuroscience News (EUA): Cannabidiol reduces aggressiveness (29/Jul/2019)
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Agenparl (Itália): Cannabidiol reduces aggressiveness, study concludes (29/Jul/2019)
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7thSpace: Cannabidiol reduces aggressiveness, study concludes (29/Jul/2019)
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CBD Olie: Cannabidiol vermindert de agressiviteit, concludeert de studi (29/Jul/2019)
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MH BioShop (Holanda): Cannabidiol vermindert de agressiviteit, concludeert de studi (29/Jul/2019)
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Hempadão: Canabidiol diminui agressividade, diz estudo da USP (28/Jul/2019)
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O Estado (MS) online: Estudo conclui que Canabidiol diminui agressividade (25/Jul/2019)
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Algomais online: Canabidiol diminui agressividade, conclui estudo (25/Jul/2019)
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Revide: Canabidiol diminui agressividade, conclui estudo feito na USP de Ribeirão Preto (24/Jul/2019)
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The Rio Times: Cannabidiol has Reduced Aggressiveness, According to Researchers From the University of São Paulo (24/Jul/2019)
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Smoke Buddies: Estudo da USP conclui que CBD reduz agressividade (23/Jul/2019)
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Sociedade Científica: Canabidiol diminui agressividade, conclui estudo (23/Jul/2019)
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Zero Hora online: Canabidiol reduz a agressividade, aponta estudo (22/Jul/2019)
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Espaço Ecológico no Ar: Canabidiol diminui agressividade, conclui estudo feito na USP em Ribeirão Preto (22/Jul/2019)
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Esteta : Canabidiol diminui agressividade, conclui estudo (22/Jul/2019)
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Metropóles: Canabidiol diminuiu agressividade, concluem pesquisadores da USP (22/Jul/2019)
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RM Consult: Canabidiol - artigo brasileiro publicado na Science Direct mostra redução de agressividade (22/Jul/2019)
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Os Cabeças da Notícia: Canabidiol diminuiu agressividade, concluem pesquisadores da USP (22/Jul/2019)
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Nossa vida de cada dia: Canabidiol diminui agressividade, diz estudo da USP – Exame (22/Jul/2019)
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W Rádio Brasil: Canabidiol diminui agressividade, conclui estudo (22/Jul/2019)
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Jornal Notícias: Canabidiol diminui agressividade, conclui estudo (22/Jul/2019)
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Portal da Enfermagem: Canabidiol diminui agressividade, conclui estudo (22/Jul/2019)
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Maryjuana: Canabidiol diminui agressividade, conclui estudo (23/Jul/2019)
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Maryjuana: Canabidiol diminui agressividade, conclui estudo (23/Jul/2019)
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Olhar Capital: Canabidiol diminui agressividade, diz estudo da USP (22/Jul/2019)
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Scientific publications
(11)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HEIMANN, ANDREA S.;
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