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New perspectives in the use of drugs that modify atypical neurotransmitters in the treatment of neuropsychiatric disorders

Grant number: 17/24304-0
Support type:Research Projects - Thematic Grants
Duration: February 01, 2019 - January 31, 2024
Field of knowledge:Biological Sciences - Pharmacology
Principal Investigator:Francisco Silveira Guimaraes
Grantee:Francisco Silveira Guimaraes
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Co-Principal Investigators:Leonardo Resstel Barbosa Moraes ; Sâmia Regiane Lourenço Joca
Assoc. researchers:Alline Cristina de Campos ; Ana Carolina de Castro Issy Pereira ; Ana Luisa Bernardes Terzian ; Antonio Cardozo dos Santos ; Ariandra Guerini Sartim ; Claudia Maria de Castro Batista ; Cristina Aparecida Jark Stern ; Daniele Cristina de Aguiar ; Elaine Aparecida Del Bel Belluz Guimarães ; Fabricio de Araujo Moreira ; Fernanda Grecco Grano ; Fernando Morgan de Aguiar Correa ; Frederico Rogério Ferreira ; Glauce Crivelaro Do Nascimento ; Leandro José Bertoglio ; Mariza Bortolanza ; Maurício dos Santos Pereira ; Nilson Carlos Ferreira Junior ; Pedro Henrique Gobira Nunes ; Rúbia Maria Monteiro Weffort de Oliveira ; Sabrina Francesca de Souza Lisboa
Associated scholarship(s):18/15896-3 - Participation of DNA methylation in rapid and sustained antidepressant-like effects induced by cannabidiol and ketamine, BP.PD
18/20433-2 - Neuroprotective and behavioral effects of the PPAR³ agonist pioglitazone in a neurodevelopmental model of schizophrenia, BP.PD

Abstract

The need to develop new therapeutic targets for the treatment of neuropsychiatric disorders is a consensus in the scientific literature. Endocannabinoids (eCBs) and nitric oxide (NO) have been proposed as two of these possible targets. Studies from our group have disclosed the therapeutic potential of drugs that interfere with these two atypical neurotransmitters in anxiety, depressive, psychotic disorders, Parkinson's disease, aggressive behavior and neurodegeneration/neurotoxicity. Cannabidiol (CBD), a non-psychotomimetic phytocannabinoid, which, among other effects, can increase the levels of the eCB anandamide, is already undergoing clinical trials to test its efficacy in some of these disorders. However, several important questions still remain related to the therapeutic potential of these drugs in other specific disorders as well as to the mechanisms involved. In the last few years our studies have indicated new possibilities, including facilitation of adult hippocampal neurogenesis and autophagy and the possible involvement of neuroinflammatory/neuroimmune mechanisms. The present project aimed at continuing this research line, trying to investigate 1. Which is the involvement and mechanisms of the anti-inflammatory effects of CBD and drugs that modify the NO and eCB system in their potential therapeutic effects?; 2. Which other neuropsychiatric disorders could benefice from these drugs?; 3. In case of co-morbities such as metabolic syndrome and anxiety disorders, in which an inflammatory component is present, would these new therapies be effective?; 4. Which other intra-cellular pathways would be involved?; 5. Which is the specific eCB involvement in the modulation of rewarding and aversive responses?; 6. Which specific epigenetic mechanisms are involved with these effects? (AU)

Articles published in Agência FAPESP Newsletter about the research grant
Cannabidiol reduces aggressiveness, study concludes 
Articles published in other media outlets (62 total):
More itemsLess items
Cannabis appears to reduce aggressiveness, study 
Cannabis : Le cannabidiol pour réduire l'agressivité 
CANNABIS : Le cannabidiol pour réduire l'agressivité 
Cannabidiol vermindert de agressiviteit, concludeert de studi 
Cannabidiol Attenuates Aggressiveness: Study 
CANNABIS : Le cannabidiol pour réduire l'agressivité 
Cannabidiol Attenuates Aggressiveness: Study 
Cannabidiol vermindert de agressiviteit, concludeert de studi 
O que já sabemos sobre o uso terapêutico do canabidiol 
In test with rats, cannabidiol showed sustained effects against depression for seven days 
O que já sabemos sobre o uso terapêutico do canabidiol 
Cannabidiol reduces aggressiveness, study concludes 
Cannabidiol reduces aggressiveness, study concludes 
Cannabidiol reduces aggressiveness, study concludes 
Cannabidiol Reduces Aggressiveness, Study Concludes 
Canabindol reduces aggressiveness, study concludes 
Study Shows CBD Reduces Aggressive Behavior 
Study finds cannabidiol can reduce isolation-induced aggression 
El cannabidiol disminuye la agresividad, de acuerdo con un estudio 
Cannabidiol Reduces Aggressiveness, Study Concludes 
CBD Mellows Out Aggressive Shut-Ins 
Could CBD reduce aggression? CBD-dosed mice half as likely to attack intruders 
Cannabidiol Reduces Aggressiveness, Study Concludes 
Cannabidiol Reduces Aggressiveness, Study Concludes 
Cannabidiol Attenuates Aggressiveness: Study 
Cannabidiol Mitigates Isolation-Induced Aggression 
Cannabidiol Reduces Aggressiveness, Study Concludes 
Cannabidiol Reduces Aggressiveness, Study Concludes 
Cannabidiol reduces aggressiveness, study concludes 
Cannabidiol Reduces Aggressiveness, Study Concludes 
Cannabidiol reduces aggressiveness, study concludes 
Cannabidiol reduces aggressiveness, study concludes 
Cannabidiol reduces aggressiveness, study concludes 
Cannabidiol Reduces Aggressiveness, Study Concludes 
Cannabidiol reduces aggressiveness, study concludes 
Cannabidiol reduces aggressiveness, study concludes 
Cannabidiol reduces aggressiveness 
Cannabidiol reduces aggressiveness, study concludes 
Cannabidiol reduces aggressiveness, study concludes 
Cannabidiol reduces aggressiveness, study concludes 
Canabidiol diminui agressividade, diz estudo da USP 
Canabidiol diminui agressividade, conclui estudo 
Estudo conclui que Canabidiol diminui agressividade 
Canabidiol diminui agressividade, conclui estudo feito na USP de Ribeirão Preto 
Cannabidiol has Reduced Aggressiveness, According to Researchers From the University of São Paulo 
Canabidiol diminui agressividade, conclui estudo 
Estudo da USP conclui que CBD reduz agressividade 
Canabidiol diminui agressividade, conclui estudo 
Canabidiol diminui agressividade, conclui estudo 
Canabidiol - artigo brasileiro publicado na Science Direct mostra redução de agressividade 
Canabidiol diminui agressividade, diz estudo da USP – Exame 
Canabidiol reduz a agressividade, aponta estudo 
Canabidiol diminui agressividade, diz estudo da USP 
Canabidiol diminui agressividade, conclui estudo 
Canabidiol diminui agressividade, conclui estudo 
Canabidiol diminuiu agressividade, concluem pesquisadores da USP 
Canabidiol diminuiu agressividade, concluem pesquisadores da USP 
Canabidiol diminui agressividade, diz estudo da USP 
Canabidiol diminui agressividade, conclui estudo 
Canabidiol diminui agressividade, conclui estudo 
Canabidiol diminui agressividade, conclui estudo 
Canabidiol diminui agressividade, conclui estudo feito na USP em Ribeirão Preto 

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HARTMANN, ALICE; LISBOA, SABRINA FRANCESCA; SONEGO, ANDREZA BUZOLIN; COUTINHO, DEBORA; GOMES, FELIPE VILLELA; GUIMARAES, FRANCISCO SILVEIRA. Cannabidiol attenuates aggressive behavior induced by social isolation in mice: Involvement of 5-HT1A and CB1 receptors. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 94, AUG 30 2019. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.