New perspectives in the use of drugs that modify atypical neurotransmitters in the treatment of neuropsychiatric disorders

• Grant number: 17/24304-0
• Support Opportunities: Research Projects - Thematic Grants
• Start date: February 01, 2019
• End date: July 31, 2024
• Field of knowledge: Biological Sciences - Pharmacology - Neuropsychopharmacology
• Principal Investigator: Francisco Silveira Guimaraes
• Grantee: Francisco Silveira Guimaraes
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• City of the host institution: Ribeirão Preto
• Principal investigators: Elaine Aparecida Del Bel Belluz Guimarães ; Leonardo Resstel Barbosa Moraes ; Sâmia Regiane Lourenço Joca
• Associated researchers: Alline Cristina de Campos ; Ana Carolina de Castro Issy Pereira ; Ana Luisa Bernardes Terzian ; Antonio Cardozo dos Santos ; Ariandra Guerini Sartim ; Claudia Maria de Castro Batista ; Cristina Aparecida Jark Stern ; Daniele Cristina de Aguiar ; Elaine Aparecida Del Bel Belluz Guimarães ; Fabricio de Araujo Moreira ; Fernanda Grecco Grano ; Fernando Morgan de Aguiar Correa ; Frederico Rogério Ferreira ; Glauce Crivelaro Do Nascimento ; Leandro José Bertoglio ; Mariza Bortolanza ; Maurício dos Santos Pereira ; Nilson Carlos Ferreira Junior ; Pedro Henrique Gobira Nunes ; Rúbia Maria Monteiro Weffort de Oliveira ; Sabrina Francesca de Souza Lisboa
• Associated scholarship(s): 23/16731-6 - Involvement of the Microbiota in the Effects of Cannabidiol in an Animal Model of Autism, BP.DR; 23/11032-2 - Pharmacological and molecular mechanisms of a fluorescent nanoprobe containing cannabidiol in neurodevelopmental disorders models: implication for autism spectrum disorder and schizophrenia., BP.DR; 24/03720-9 - Study of the effects of chronic treatment with cannabidiol orally administered on the microbiota profile in mice, BP.IC; + associated scholarships 23/06251-7 - Training in techniques for breeding and maintaince of Cre-LoxP trangenic mice, BP.TT; 22/09348-9 - Investigation of the involvement of adenosinergic neurotransmission in the behavioral effects of cannabidiol: participation of serotoninergic 5-HT1A and CB1 cannabinoid receptors., BP.MS; 22/10858-1 - Characterization of the effect of cannabidiol, ketamine and classical antidepressants in male and female mice of the CD-1 strain in the forced swimming test, BP.IC; 21/02873-8 - Cannabinoids and doxycycline interaction in an experimental tardive dyskinesia model, BP.MS; 22/00198-4 - Involvement of nitric oxide with the behavioural and molecular changes induced by exposure to an intense stressor: possible effect of cannabidiol, BP.PD; 22/00197-8 - Involvement of the medial prefrontal cortex (mPFC) in the rapid and sustained effect of drugs in a model of depression resistant to conventional antidepressants: possible involvement of endocannabinoid modulation on the cortical glutamatergic system, BP.PD; 21/12917-2 - New perspectives on the use of drugs that modify atypical neurotransmitters in the treatment of neuropsychiatric disorders, BP.TT; 20/02297-4 - Conditioned and unconditioned stimulus send at fixed or randomized intervals: possible behavioral differences for the expression and extinction of conditioned fear memory., BP.IC; 20/04145-7 - Investigation of the possible involvement of adenosinergic receptors in the behavioral effects induced by cannabidiol in mice using different animal models, BP.IC; 19/26351-0 - Evaluation of paclitaxel-induced cognitive deficits in a 4T-1 murine mammary carcinoma model and possible protective effect of concomitant cannabidiol treatment., BP.IC; 19/24591-4 - Mechanisms of cannabidiol antipsychotics effects in schizophrenia model based in neurodevelopment variation, BP.DR; 19/18846-0 - Role of the endocannabinoid system in orofacial muscular pain related to Parkinson's Disease, BP.IC; 19/26810-5 - Extracellular Vesicles as Signals of the Hippocampal Neurogenic Niche: Participation in the Behavioral Effects of cannabinoid and antidepressant drugs, BP.PD; 18/15896-3 - Participation of DNA methylation in rapid and sustained antidepressant-like effects induced by Cannabidiol and Ketamine, BP.PD; 18/20433-2 - Neuroprotective and behavioral effects of the PPAR³ agonist pioglitazone in a neurodevelopmental model of schizophrenia, BP.PD; 17/14207-7 - THE ACTION OF CANNABINOID DRUGS IN L-DOPA-INDUCED DISCINESIA: ANALYSIS OF NEUROINFLAMATION AND GLUTAMATE RELEASE IN GLIAL CELLS, BP.PD - associated scholarships

Abstract

The need to develop new therapeutic targets for the treatment of neuropsychiatric disorders is a consensus in the scientific literature. Endocannabinoids (eCBs) and nitric oxide (NO) have been proposed as two of these possible targets. Studies from our group have disclosed the therapeutic potential of drugs that interfere with these two atypical neurotransmitters in anxiety, depressive, psychotic disorders, Parkinson's disease, aggressive behavior and neurodegeneration/neurotoxicity. Cannabidiol (CBD), a non-psychotomimetic phytocannabinoid, which, among other effects, can increase the levels of the eCB anandamide, is already undergoing clinical trials to test its efficacy in some of these disorders. However, several important questions still remain related to the therapeutic potential of these drugs in other specific disorders as well as to the mechanisms involved. In the last few years our studies have indicated new possibilities, including facilitation of adult hippocampal neurogenesis and autophagy and the possible involvement of neuroinflammatory/neuroimmune mechanisms. The present project aimed at continuing this research line, trying to investigate 1. Which is the involvement and mechanisms of the anti-inflammatory effects of CBD and drugs that modify the NO and eCB system in their potential therapeutic effects?; 2. Which other neuropsychiatric disorders could benefice from these drugs?; 3. In case of co-morbities such as metabolic syndrome and anxiety disorders, in which an inflammatory component is present, would these new therapies be effective?; 4. Which other intra-cellular pathways would be involved?; 5. Which is the specific eCB involvement in the modulation of rewarding and aversive responses?; 6. Which specific epigenetic mechanisms are involved with these effects? (AU)

Scientific publications

(71)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

MEYER, ERIKA; BONATO, JESSICA MENDES; MORI, MARCO AURELIO; MATTOS, BIANCA ANDRETTO; GUIMARAES, FRANCISCO SILVEIRA; MILANI, HUMBERTO; DE CAMPOS, ALLINE CRISTINA; WEFFORT DE OLIVEIRA, RUBIA MARIA. Cannabidiol Confers Neuroprotection in Rats in a Model of Transient Global Cerebral Ischemia: Impact of Hippocampal Synaptic Neuroplasticity. Molecular Neurobiology, v. 58, n. 10, JUL 2021. (17/24304-0)

HARTMANN, ALICE; LISBOA, SABRINA FRANCESCA; SONEGO, ANDREZA BUZOLIN; COUTINHO, DEBORA; GOMES, FELIPE VILLELA; GUIMARAES, FRANCISCO SILVEIRA. Cannabidiol attenuates aggressive behavior induced by social isolation in mice: Involvement of 5-HT1A and CB1 receptors. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 94, AUG 30 2019. (16/14282-6, 10/17343-0, 17/24304-0, 11/22523-0, 17/19731-6)

ASTH, LAILA; CRUZ, LEONARDO CARDOSO; SOYOMBO, NICHOLAS; RIGO, PEDRO; MOREIRA, FABRICIO A.. Effects of beta-caryophyllene, A Dietary Cannabinoid, in Animal Models of Drug Addiction. Current Neuropharmacology, v. 21, n. 2, p. 6-pg., 2023-01-01. (17/24304-0)

ULIANA, DANIELA L.; ANTERO, LEANDRO S.; BORGES-ASSIS, ANNA B.; ROSA, JESSICA; VILA-VERDE, CARLA; LISBOA, SABRINA F.; RESSTEL, LEONARDO B. M.. Differential modulation of the contextual conditioned emotional response by CB1 and TRPV1 receptors in the ventromedial prefrontal cortex: Possible involvement of NMDA/nitric oxide-related mechanisms. JOURNAL OF PSYCHOPHARMACOLOGY, v. 34, n. 9, JUL 2020. (17/24304-0, 17/14473-9)

BATISTA, LUARA AUGUSTA; DE ARAUJO MOREIRA, FABRICIO; DE AGUIAR, DANIELE CRISTINA. Interactions between the nitrergic and the endocannabinoid system in rats exposed to the elevated T-maze. ACTA NEUROPSYCHIATRICA, v. 33, n. 4, p. 206-210, AUG 2021. (17/24304-0)

SILVA, NICOLE RODRIGUES; GOMES, FRANCISCO ISAAC FERNANDES; LOPES, ALEXANDRE HASHIMOTO PEREIRA; CORTEZ, ISADORA LOPES; DOS SANTOS, JESSICA CRISTINA; SILVA, CONCEICAO ELIDIANNE ANIBAL; MECHOULAM, RAPHAEL; GOMES, FELIPE VILLELA; CUNHA, THIAGO MATTAR; GUIMARAES, FRANCISCO SILVEIRA. The Cannabidiol Analog PECS-101 Prevents Chemotherapy-Induced Neuropathic Pain via PPAR gamma Receptors. NEUROTHERAPEUTICS, DEC 2021. (17/24304-0)

GAZARINI, LUCAS; STERN, CRISTINA A. J.; BERTOGLIO, LEANDRO J.. On making (and turning adaptive to) maladaptive aversive memories in laboratory rodents. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, v. 147, p. 36-pg., 2023-02-21. (17/24304-0)

RIBEIRO, MELISSA A.; AGUIAR, RAFAEL P.; SCARANTE, FRANCIELE F.; FUSSE, EDUARDO J.; DE OLIVEIRA, RUBIA M. W.; GUIMARAES, FRANCISCO S.; CAMPOS, ALLINE C.. pontaneous Activity of CB2 Receptors Attenuates Stress-Induced Behavioral and Neuroplastic Deficits in Male Mic. FRONTIERS IN PHARMACOLOGY, v. 12, JAN 21 2022. (17/24304-0, 15/05551-0)

ASTH, LAILA; SANTOS, ALINE C.; MOREIRA, FABRICIO A.. The endocannabinoid system and drug-associated contextual memories. Behavioural Pharmacology, v. 33, n. 2-3, p. 15-pg., 2022-04-01. (17/24304-0)

CORTEZ, ISADORA LOPES; SILVA, NICOLE R.; RODRIGUES, NAIELLY S.; PEDRAZZI, JOAO FRANCISCO C.; DEL BEL, ELAINE A.; MECHOULAM, RAPHAEL; GOMES, FELIPE, V; GUIMARAES, FRANCISCO S.. HU-910, a CB2 receptor agonist, reverses behavioral changes in pharmacological rodent models for schizophrenia. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 117, p. 9-pg., 2022-07-13. (17/24304-0)

GOBIRA, P. H.; JOCA, S. R.; MOREIRA, F. A.. Roles of cannabinoid CB1 and CB2 receptors in the modulation of psychostimulant responses. ACTA NEUROPSYCHIATRICA, v. N/A, p. 11-pg., 2022-08-22. (17/24304-0, 17/19284-0)

FRANZEN, JAQUELINE M.; WERLE, ISABEL; VANZ, FELIPE; DE OLIVEIRA, BRUNO BISCAIA; NASCIMENTO, LAURA MARIA MARTINS; GUIMARAES, FRANCISCO S.; BERTOGLIO, LEANDRO J.. Cannabidiol attenuates fear memory expression in female rats via hippocampal 5-HT(1A )but not CB1 or CB2 receptors. Neuropharmacology, v. 223, p. 10-pg., 2023-02-01. (17/24304-0)

PEDRAZZI, J. F. C.; SALES, A. J.; PONCIANO, R. S. M.; FERREIRA, L. G.; FERREIRA, F. R.; CAMPOS, A. C.; HALLAK, J. E. C.; ZUARDI, A. W.; DEL BELAD, E. A.; GUIMARAES, F. S.; et al. Acute cannabidiol treatment reverses behavioral impairments induced by embryonic valproic acid exposure in male mice. Pharmacology Biochemistry and Behavior, v. 247, p. 9-pg., 2024-12-17. (22/05199-9, 17/24304-0)

CARDOSO, NATHALIE CARLA; SOHN, JEFERSON MACHADO BATISTA; RAYMUNDI, ANA MARIA; SANTOS, MATEUS REIS; PRICKAERTS, JOS; GAZARINI, LUCAS; STERN, CRISTINA APARECIDA JARK. Time-dependent fear memory generalization triggered by phosphodiesterase 5 inhibition during reconsolidation. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 137, p. 13-pg., 2025-03-20. (17/24304-0)

DE ANDRADE, VICTOR H. B.; RODRIGUES, ERICK Y. M.; DIAS, NAYARA A. F.; FERREIRA, GABRIELA F. C.; DE CARVALHO, DIEGO B.; DAS NEVES, AMARITH R.; CORONEL, PAOLA M. V.; YONEKAWA, MURILO K. A.; PARISOTTO, EDUARDO B.; DOS SANTOS, EDSON A.; et al. Neuroprotective Profile of Triazole Grandisin Analogue against Amyloid-Beta Oligomer-Induced Cognitive Impairment. ACS Chemical Neuroscience, v. 14, n. 24, p. 13-pg., 2023-12-04. (17/24304-0)

BERTACCHINI, GABRIELA L.; SONEGO, ANDREZA B.; LISBOA, SABRINA S. F.; LAGATTA, DAVI C.; RESSTEL, LEONARDO B. M.. The expression of contextual fear conditioning involves the dorsal hippocampus TRPV1 receptor interacting with the NMDA/NO/cGMP signalling pathway. British Journal of Pharmacology, v. N/A, p. 14-pg., 2024-11-12. (17/24304-0, 13/08674-0, 17/14473-9)

JACOB, GABRIELLE; MILAN, BRUNA A.; ANTONIETO, LIVIA RODRIGUES; LEVI, YARA; RIBEIRO, MARCELA COSTA; NASSAR, RAQUEL; DE SOUSA-NETO, MANOEL DAMIAO; MAZZI-CHAVES, JARDEL FRANCISCO; MESSORA, MICHEL REIS; FURLANETO, FLAVIA APARECIDA CHAVES; et al. Experimental Periodontitis Worsens Dopaminergic Neuronal Degeneration. JOURNAL OF CLINICAL PERIODONTOLOGY, v. N/A, p. 12-pg., 2024-09-02. (17/24304-0, 23/01986-9, 22/02050-4)

VAZ, GABRIELA N.; TURCATO, FLAVIA C.; LIMA, ISABEL A., V; SCARANTE, FRANCIELE F.; ARAUJO, MELISSA R.; BRIGANTE, TAMIRES A., V; RODRIGUES, LIVIA C. M.; GUIMARAES, FRANCISCO S.; HALLAK, JAIME E. C.; CRIPPA, JOSE A.; et al. Genetic ablation of the isoform γ of PI3K decreases antidepressant efficacy of ketamine in male mice. IBRO NEUROSCIENCE REPORTS, v. 17, p. 9-pg., 2024-06-24. (17/24304-0, 15/05551-0)

NASCIMENTOA, GLAUCE CRIVELARO; VIVANCO-ESTELAA, AIRAM NICOLE; FERRIE, LAURENT; FIGADERE, BRUNO; RAISMAN-VOZARI, RITA; MICHEL, PATRICK PIERRE; DEL BELA, ELAINE. Glauce Crivelaro Nascimentoa, a , Airam Nicole Vivanco-Estelaa, a , Laurent Ferrieb, b , Bruno Figadere b , Rita Raisman-Vozari c , Patrick Pierre Michel c , Elaine Del Bela,* a,*. European Journal of Pharmacology, v. 984, p. 13-pg., 2024-10-17. (17/24304-0)

BERTACCHINI, GABRIELA L.; SONEGO, ANDREZA B.; WERWORN, LARISSA FERNANDA M.; SOLOVI, SARAH R.; RESSTEL, LEONARDO B. M.. The conditioned emotional response evoked by contextual fear is modulated by lateral hypothalamus synaptic activity without the involvement of GABAA receptor activation. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 141, p. 12-pg., 2025-08-30. (13/08674-0, 17/14473-9, 17/24304-0)

WERLE, ISABEL; BERTOGLIO, LEANDRO J.. Psychedelics: A review of their effects on recalled aversive memories and fear/anxiety expression in rodents. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, v. 167, p. 31-pg., 2024-09-24. (17/24304-0)

ESCOBAR-ESPINAL, DANIELA MARIA; VIVANCO-ESTELA, AIRAM NICOLE; BARROS, NUBIA; PEREIRA, MAURICIO DOS SANTOS; GUIMARAES, FRANCISCO SILVEIRA; DEL BEL, ELAINE; NASCIMENTO, GLAUCE C.. Cannabidiol and it fluorinate analog PECS-101 reduces hyperalgesia and allodynia in trigeminal neuralgia via TRPV1 receptors. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 132, p. 12-pg., 2024-03-21. (17/24304-0)

BRIANIS, RAYSSA C.; LIMA, RITA C.; MOREIRA, FABRICIO A.; AGUIAR, DANIELE C.. Anti-aversive effect of 2-arachidonoylglycerol in the dorsolateral periaqueductal gray of male rats in contextual fear conditioning and Vogel tests. Behavioural Pharmacology, v. 33, n. 2-3, p. 9-pg., 2022-04-01. (17/24304-0)

RAYMUNDI, ANA MARIA; DA SILVA, THIAGO R.; ZAMPRONIO, ALEKSANDER R.; GUIMARAES, FRANCISCO S.; BERTOGLIO, LEANDRO J.; STERN, CRISTINA A. J.. A time-dependent contribution of hippocampal CB1, CB2 and PPAR gamma receptors to cannabidiol-induced disruption of fear memory consolidation. British Journal of Pharmacology, v. 177, n. 4, p. 13-pg., 2020-01-21. (17/24304-0)

DOS SANTOS PEREIRA, MAURICIO; ABREU, GABRIEL HENRIQUE DIAS; ROCCA, JEREMY; HAMADAT, SABAH; RAISMAN-VOZARI, RITA; MICHEL, PATRICK PIERRE; DEL BEL, ELAINE. Contributive Role of TNF-alpha to L-DOPA-Induced Dyskinesia in a Unilateral 6-OHDA Lesion Model of Parkinson's Disease. FRONTIERS IN PHARMACOLOGY, v. 11, JAN 11 2021. (14/25029-4, 18/03482-0, 17/24304-0, 17/14207-7)

HEIMANN, ANDREA S.; DALE, CAMILA S.; GUIMARAES, FRANCISCO S.; REIS, RICARDO A. M.; NAVON, AMI; SHMUELOV, MICHAL A.; RIOLI, VANESSA; GOMES, IVONE; DEVI, LAKSHMI L.; FERRO, EMER S.. Hemopressin as a breakthrough for the cannabinoid field. Neuropharmacology, v. 183, FEB 1 2021. (16/04000-3, 19/06982-6, 17/24304-0)

BORGES-ASSIS, ANNA BARBARA; ULIANA, DANIELA LESCANO; HOTT, SARA CRISTINA; GUIMARA, FRANCISCO SILVEIRA; LISBOA, SABRINA FRANCESCA; RESSTEL, LEONARDO BARBOSA MORAES. Bed nucleus of the stria terminalis CB1 receptors and the FAAH enzyme modulate anxiety behavior depending on previous stress exposure. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 125, p. 12-pg., 2023-07-13. (17/16913-6, 17/24304-0, 12/17626-7, 17/19731-6)

FRANZEN, JAQUELINE M.; VANZ, FELIPE; WERLE, ISABEL; GUIMARAES, FRANCISCO S.; BERTOGLIO, LEANDRO J.. Cannabidiol impairs fear memory reconsolidation in female rats through dorsal hippocampus CB1 but not CB2 receptor interaction. European Neuropsychopharmacology, v. 64, p. 12-pg., 2022-08-29. (17/24304-0)

BORTOLANZA, MARIZA; DO NASCIMENTO, GLAUCE C.; RAISMAN-VOZARI, RITA; DEL-BEL, ELAINE. Doxycycline and its derivative, COL-3, decrease dyskinesia induced by l-DOPA in hemiparkinsonian rats. British Journal of Pharmacology, v. 178, n. 13, APR 2021. (14/25029-4, 17/24304-0)

ZADOR, FERENC; JOCA, SAMIA; NAGY-GROCZ, GABOR; DVORACSKO, SZABOLCS; SZUCS, EDINA; TOMBOLY, CSABA; BENYHE, SANDOR; VECSEI, LASZLO. Pro-Inflammatory Cytokines: Potential Links between the Endocannabinoid System and the Kynurenine Pathway in Depression. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, n. 11, JUN 2021. (17/24304-0)

GONZALEZ-LIZARRAGA, FLORENCIA L.; PLOPER, DIEGO; AVILA, CESAR L.; SOCIAS, SERGIO B.; DOS-SANTOS-PEREIRA, MAURICIO; MACHIN, BELEN; DEL-BEL, ELAINE; MICHEL, PATRICK PIERRE; PIETRASANTA, I, LIA; RAISMAN-VOZARI, RITA; et al. CMT-3 targets different alpha-synuclein aggregates mitigating their toxic and inflammogenic effects. SCIENTIFIC REPORTS, v. 10, n. 1, NOV 20 2020. (17/24304-0, 18/03482-0, 14/25029-4, 17/14207-7)

SANADGOL, NIMA; FERIZ, ADIB MIRAKI; LISBOA, SABRINA F.; JOCA, SAMIA R. L.. Putative role of glial cells in treatment resistance depression: An updated critical literation review and evaluation of single-nuclei transcriptomics data. Life Sciences, v. 331, p. 12-pg., 2023-08-28. (17/24304-0, 18/24140-0, 17/19731-6)

COLODETE, DEBORA A. E.; SILVA, NICOLE R.; PEDRAZZI, JOAO FRANCISCO C.; FOGACA, MANOELA V.; CORTEZ, ISADORA; DEL-BEL, ELAINE A.; BREUER, AVIVA; MECHOULAM, RAPHAEL; GOMES, FELIPE V.; GUIMARAES, FRANCISCO S.. Behavioral effects induced by the cannabidiol analogs HU-502 and HU-556. Behavioural Pharmacology, v. 34, n. 4, p. 12-pg., 2023-06-01. (17/24304-0)

MACIEL, IZAQUE DE SOUSA; SALES, AMANDA J.; CASAROTTO, PLINIO C.; CASTREN, EERO; BIOJONE, CAROLINE; JOCA, SAMIA R. L.. Nitric Oxide Synthase inhibition counteracts the stress-induced DNA methyltransferase 3b expression in the hippocampus of rats. European Journal of Neuroscience, DEC 2020. (15/25067-6, 15/06271-1, 17/24304-0)

LOPES, JADNA B.; BASTOS, JULIANA R.; COSTA, RAYSSA B.; AGUIAR, DANIELE C.; MOREIRA, FABRICIO A.. The roles of cannabinoid CB1 and CB2 receptors in cocaine-induced behavioral sensitization and conditioned place preference in mice. Psychopharmacology, OCT 2019. (17/24304-0)

RAYMUNDI, ANA MARIA; DA SILVA, THIAGO R.; ZAMPRONIO, ALEKSANDER R.; GUIMARAES, FRANCISCO S.; BERTOGLIO, LEANDRO J.; STERN, CRISTINA A. J.. A time-dependent contribution of hippocampal CB1, CB2 and PPAR gamma receptors to cannabidiol-induced disruption of fear memory consolidation. British Journal of Pharmacology, v. 177, n. 4, SI, JAN 2020. (17/24304-0)

DA SILVA, NAIELLY RODRIGUES; GOMES, FELIPE VILLELA; SONEGO, ANDREZA BUZOLIN; DA SILVA, NICOLE RODRIGUES; GUIMARAES, FRANCISCO SILVEIRA. Cannabidiol attenuates behavioral changes in a rodent model of schizophrenia through 5-HT1A, but not CB1 and CB2 receptors. PHARMACOLOGICAL RESEARCH, v. 156, JUN 2020. (17/24304-0, 18/17597-3)

IGLESIAS, LIA P.; AGUIAR, DANIELE C.; MOREIRA, FABRICIO A.. TRPV1 blockers as potential new treatments for psychiatric disorders. Behavioural Pharmacology, v. 33, n. 1, p. 2-14, FEB 2022. (17/24304-0)

SILVEIRA, KENNIA M.; WEGENER, GREGERS; JOCA, SAMIA R. L.. Targeting 2-arachidonoylglycerol signalling in the neurobiology and treatment of depression. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, v. 129, n. 1, p. 3-14, JUL 2021. (17/24304-0)

ROPKE, JIVAGO; FERREIRA-VIEIRA, TALITA H.; IGLESIAS, LIA P.; ASTH, LAILA; RIBEIRO, FABIOLA M.; MOREIRA, FABRICIO A.. Protective role of endocannabinoid signaling in an animal model of haloperidol-induced tardive dyskinesia. Pharmacology Biochemistry and Behavior, v. 206, JUL 2021. (17/24304-0)

MOHAMMAD, GULDAR SAYED; JOCA, SAMIA; STARNAWSKA, ANNA. The Cannabis-Induced Epigenetic Regulation of Genes Associated with Major Depressive Disorder. GENES, v. 13, n. 8, p. 15-pg., 2022-08-01. (17/24304-0)

SANTOS-LOBATO, BRUNO L.; BORTOLANZA, MARIZA; PINHEIRO, LUCAS CESAR; BATALHAO, MARCELO E.; PIMENTEL, ANGELA V.; CAPELLARI-CARNIO, EVELIN; DEL-BEL, ELAINE A.; TUMAS, VITOR. Levodopa-induced dyskinesias in Parkinson's disease increase cerebrospinal fluid nitric oxide metabolites' levels. JOURNAL OF NEURAL TRANSMISSION, v. 129, n. 1, DEC 2021. (17/24304-0, 12/17626-7)

CORTEZ, ISADORA L.; RODRIGUES DA SILVA, NAIELLY; GUIMARAES, FRANCISCO S.; GOMES, FELIPE V.. Are CB2 Receptors a New Target for Schizophrenia Treatment?. FRONTIERS IN PSYCHIATRY, v. 11, OCT 30 2020. (17/24304-0, 18/17597-3)

MACIEL, IZAQUE DE SOUSA; SALES, AMANDA J.; CASAROTTO, PLINIO C.; CASTREN, EERO; BIOJONE, CAROLINE; JOCA, SAMIA R. L.. Nitric Oxide Synthase inhibition counteracts the stress-induced DNA methyltransferase 3b expression in the hippocampus of rats. European Journal of Neuroscience, v. 55, n. 9-10, p. 14-pg., 2020-12-06. (15/25067-6, 15/06271-1, 17/24304-0)

PEDRAZZI, JOAO F. C.; SALES, AMANDA J.; GUIMARAES, FRANCISCO S.; JOCA, SAMIA R. L.; CRIPPA, JOSE A. S.; DEL BEL, ELAINE. annabidiol prevents disruptions in sensorimotor gating induced by psychotomimetic drugs that last for 24-h with probable involvement of epigenetic changes in the ventral striatu. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v. 111, DEC 20 2021. (15/06515-8, 14/25029-4, 17/24304-0)

GOBIRA, P. H.; RONCALHO, A. L.; SILVA, N. R.; SILOTE, G. P.; SALES, A. J.; JOCA, S. R.. Adolescent cannabinoid exposure modulates the vulnerability to cocaine-induced conditioned place preference and DNMT3a expression in the prefrontal cortex in Swiss mice. Psychopharmacology, v. 238, n. 11, JUL 2021. (17/19284-0, 17/24304-0)

ASTH, LAILA; IGLESIAS, LIA P.; BRIANIS, RAYSSA C.; MARCAL, ANNA P.; SOARES, NICIA P.; AGUIAR, DANIELE C.; MOREIRA, FABRICIO A.. Effects of the monoamine stabilizer, (-)-OSU6162, on cocaine-induced locomotion and conditioned place preference in mice. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, v. 394, n. 6, JAN 2021. (17/24304-0)

SCARANTE, FRANCIELE F.; RIBEIRO, MELISSA A.; ALMEIDA-SANTOS, ANA F.; GUIMARAES, FRANCISCO S.; CAMPOS, ALLINE C.. Glial Cells and Their Contribution to the Mechanisms of Action of Cannabidiol in Neuropsychiatric Disorders. FRONTIERS IN PHARMACOLOGY, v. 11, FEB 4 2021. (19/25984-0, 19/09178-3, 17/24304-0)

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