Efficacy of Antimicrobial Photodynamic Therapy Mediated by Photosensitizers Conjugated with Inorganic Nanoparticles: Systematic Review and Meta-Analysis

Author(s)

Ferrisse, Tulio Morandin ; Dias, Luana Mendonca ; de Oliveira, Analu Barros ; Jordao, Claudia Carolina ; de Oliveira Mima, Ewerton Garcia ; Pavarina, Ana Claudia

• Document type: Journal article
• Source: PHARMACEUTICS; v. 14, n. 10, p. 18-pg., 2022-10-01.

Abstract

Antimicrobial photodynamic therapy (aPDT) is a method that does not seem to promote antimicrobial resistance. Photosensitizers (PS) conjugated with inorganic nanoparticles for the drug-delivery system have the purpose of enhancing the efficacy of aPDT. The present study was to perform a systematic review and meta-analysis of the efficacy of aPDT mediated by PS conjugated with inorganic nanoparticles. The PubMed, Scopus, Web of Science, Science Direct, Cochrane Library, SciELO, and Lilacs databases were searched. OHAT Rob toll was used to assess the risk of bias. A random effect model with an odds ratio (OR) and effect measure was used. Fourteen articles were able to be included in the present review. The most frequent microorganisms evaluated were Staphylococcus aureus and Escherichia coli, and metallic and silica nanoparticles were the most common drug-delivery systems associated with PS. Articles showed biases related to blinding. Significant results were found in aPDT mediated by PS conjugated with inorganic nanoparticles for overall reduction of microorganism cultured in suspension (OR = 0.19 [0.07; 0.67]/p-value = 0.0019), E. coli (OR = 0.08 [0.01; 0.52]/p-value = 0.0081), and for Gram-negative bacteria (OR = 0.12 [0.02; 0.56/p-value = 0.0071). This association approach significantly improved the efficacy in the reduction of microbial cells. However, additional blinding studies evaluating the efficacy of this therapy over microorganisms cultured in biofilm are required. (AU)

• FAPESP's process: 19/27634-6 - Evaluation effect of DNAse-associated antimicrobial photodynamic therapy in the treatment of Oral Candidosis in mice infected with Candida albicans
• Grantee: Cláudia Carolina Jordão
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 20/07110-0 - Potential of photodynamic therapy in modulating the inflammatory response and microbial virulence factors: evaluation in a model of three-dimensional co-cultures of gingival fibroblasts, Candida albicans and Staphylococcus aureus
• Grantee: Analú Barros de Oliveira
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 20/16227-8 - Influence of photodynamic therapy combined with antimicrobial peptides on Candida albicans biofilm and 3D cell culture
• Grantee: Luana Mendonça Dias Santana
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 21/01191-0 - Tolerance induction and Candida albicans's biofilm characterization after antimicrobial photodymamic therapy application
• Grantee: Túlio Morandin Ferrisse
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 13/07276-1 - CEPOF - Optics and Photonic Research Center
• Grantee: Vanderlei Salvador Bagnato
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC