Butyrate: Connecting the gut-lung axis to the management of pulmonary disorders

Author(s)

Correa, Renan Oliveira ; Castro, Pollyana Ribeiro ; Moser, Rene ; Ferreira, Caroline Marcantonio ; Quesniaux, Valerie F. J. ; Ramirez Vinolo, Marco Aurelio ; Ryffel, Bernhard

• Document type: Journal article
• Source: FRONTIERS IN NUTRITION; v. 9, p. 16-pg., 2022-10-20.

Abstract

Short-chain fatty acids (SCFAs) are metabolites released by bacterial components of the microbiota. These molecules have a wide range of effects in the microbiota itself, but also in host cells in which they are known for contributing to the regulation of cell metabolism, barrier function, and immunological responses. Recent studies indicate that these molecules are important players in the gut-lung axis and highlight the possibility of using strategies that alter their intestinal production to prevent or treat distinct lung inflammatory diseases. Here, we review the effects of the SCFA butyrate and its derivatives in vitro and in vivo on murine models of respiratory disorders, besides discussing the potential therapeutic use of butyrate and the other SCFAs in lung diseases. (AU)

• FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
• Grantee: Licio Augusto Velloso
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 18/15313-8 - Investigation of the molecular mechanisms involved in the interaction between microbiota-derived metabolites and host cells during inflammation
• Grantee: Marco Aurélio Ramirez Vinolo
• Support Opportunities: Research Grants - Young Investigators Grants - Phase 2