Exploiting mesoporous silica, silver and gold nanoparticles for neurodegenerative diseases treatment

Author(s)

Ribeiro, Tais C. ; Sabio, Rafael M. ; Carvalho, Gabriela C. ; Fonseca-Santos, Bruno ; Chorilli, Marlus

• Document type: Journal article
• Source: International Journal of Pharmaceutics; v. 624, p. 16-pg., 2022-07-07.

Abstract

Neurodegenerative diseases (NDs) are considered public health problem characterized by neural loss causing cognitive and behavioral impairments. It is currently possible to use drugs capable of controlling the symptoms caused by these diseases. However, treatment is not able to prevent neural loss. In addition, poor solubility, low bioavailability due to the inability for crossing the blood-brain barrier (BBB) are described as the main limitations of the treatment. Nanotechnology involves the development of nanoscale drug delivery systems and they have been employed to optimize therapeutics face to several diseases treatment. In light of this, this review describes the highlights on the fabrication of nanotechnology-based drug delivery systems emphasizing mesoporous silica, gold and silver nanoparticles (MSNs, AuNPs and AgNPs, respectively) and their biological behavior for the treatment of Alzheimer's and Parkinson diseases (ADs and PDs, respectively). (AU)

• FAPESP's process: 19/26821-7 - Nano-in-nano containing curcumin and benzydamine hydrochloride for the treatment of Vulvovaginal Candidiasis: from development to biological application in vitro and in vivo
• Grantee: Gabriela Corrêa Carvalho
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 19/19228-8 - Evaluation of curcumin potential incorporated in mesoporous silica nanoparticles dispersed in thermo-responsive hydrogels in the treatment of Alzheimer's Disease
• Grantee: Tais de Cassia Ribeiro
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 18/25377-3 - Potential evaluation of cetuximab-modified mesoporous silica nanoparticles as docetaxel carrier to prostate cancer treatment.
• Grantee: Rafael Miguel Sábio
• Support Opportunities: Scholarships in Brazil - Post-Doctoral