Voltammetric sensors containing mesoporous Silica modified with gold nanoparticles and nitroheterocyclic compounds with antichagasic activity - Bioelectrochemical Applications.

• Grant number: 13/16960-3
• Support Opportunities: Scholarships in Brazil - Post-Doctorate
• Effective date (Start): November 01, 2013
• Effective date (End): October 31, 2014
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Silvia Helena Pires Serrano
• Grantee: Iranaldo Santos da Silva
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The negligible diseases (Chagas, Leishmaniasis and Malaria) still represent nowadays a major public health problem. The biological activity of the compounds with antichagasic properties is closely related to the free radicals action, which are derivative from the monoeletronic reduction of nitro groups in the heterocyclic compounds. The electrochemical behavior of three new compounds with antichagasic properties will be studied using voltammetric techniques (cyclic voltammetry, differential pulse and square wave). As working electrodes it will be used: glassy carbon electrode (GCE), to characterize the drug electrochemical behavior in solution (mixed and aprotic media) and the carbon paste electrode (CPE), previously modified by incorporation of the water insoluble nitro compounds in the carbon paste composition (using the solid state voltammetry). Both working electrodes will still be modified using mesoporous silica FDU-12, containing lignin and gold nanoparticles. From these studies and the experimental reducing potential values it will be possible to correlate the reducing potential of these compounds with their biological.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERREIRA, ANA PAULA M.; DOS SANTOS PEREIRA, LAISE N.; DA SILVA, IRANALDO SANTOS; TANAKA, SONIA M. C. N.; TANAKA, AURO A.; ANGNES, LUCIO. Determination of alpha-Lipoic acid on a Pyrolytic Graphite Electrode Modified with Cobalt Phthalocyanine. Electroanalysis, v. 26, n. 10, p. 2138-2144, OCT 2014. (13/16960-3)