Association between ADHD symptoms and inhibition-related brain activity using functional near-infrared spectroscopy (fNIRS)

Author(s)

Afonso Junior, Armando dos Santos ; Machado-Pinheiro, Walter ; Caldas Osorio, Ana Alexandra ; Seabra, Alessandra Gotuzo ; Triguero Veloz Teixeira, Maria Cristina ; Nascimento, Julia de Araujo ; Rodrigues Carreiro, Luiz Renato

• Document type: Journal article
• Source: Neuroscience Letters; v. 792, p. 6-pg., 2023-01-01.

Abstract

Attention deficit hyperactivity disorder (ADHD) is associated with deficits in inhibitory functions including interference control, inhibition of prepotent/automatic responses and suppression of already initiated responses. This study used functional near-infrared spectroscopy (fNIRS) to investigate the neural basis of these three forms of inhibition assessed by a recently developed behavioral protocol combining the Stroop-matching/stop-signal task in twenty-five young adults with inattention, impulsivity and/or hyperactivity symptoms. The severity of ADHD symptoms was measured using the Adult ADHD Self-Report Scale (ASRS). The concentration of oxygenated hemoglobin (HbO) was assessed in the dorsolateral prefrontal cortex (DLPFC), inferior frontal gyrus (IFG) and temporoparietal regions (TP) during the Stroop-matching/stop-signal task. Correlations yielded sig-nificant associations between ASRS scores and HbO concentration in frontal regions during blocks with stop -signal tasks, namely the right IFG, the left DLPFC and the left IFG. This study revealed that different types of inhibition involve unique frontal and temporoparietal activities and linked frontal dysfunction during the sup-pression of ongoing responses to the severity of ADHD symptoms. (AU)

• FAPESP's process: 20/14800-2 - Biological measures recordig during the execution of computerized tests of attention and inhibition.
• Grantee: Julia de Araujo Nascimento
• Support Opportunities: Scholarships in Brazil - Technical Training Program - Technical Training
• FAPESP's process: 19/21773-4 - Electromyography and functional neuroimaging markers associated with inhibitory processes in young adults with ADHD
• Grantee: Armando dos Santos Afonso Junior
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 19/20757-5 - Neurophysiological and behavioral measures associated with attentional and inhibitory processes in adult young with ADHD
• Grantee: Luiz Renato Rodrigues Carreiro
• Support Opportunities: Regular Research Grants