Dataset of dual RNA-seq mapping in visceral leishmaniasis: Inquiry on parasite transcripts in human blood transcriptome upon Leishmania infantum infection

Author(s)

Gomes, Ellen ; Rogerio, Luana Aparecida ; Takamiya, Nayore Tamie ; Torres, Caroline ; da Silva, Joao Santana ; Almeida, Roque Pacheco ; Maruyama, Sandra Regina

• Document type: Journal article
• Source: DATA IN BRIEF; v. 46, p. 7-pg., 2022-12-17.

Abstract

This dataset is related to the article "Insight Into the Long Noncoding RNA and mRNA Coexpression Profile in the Hu-man Blood Transcriptome Upon Leishmania infantum Infec-tion " by S.R. Maruyama, C.A. Fuzo, A .E.R. Oliveira, L.A . Roge-rio, N.T. Takamiya, G. Pessenda, E.V. de Melo, A.M. da Silva, A.R. Jesus, V. Carregaro, H.I. Nakaya, R.P. Almeida and J.S. da Silva. Frontiers in Immunology, 2022. Through the reuse of raw sequencing data, we generated original dataset by per-forming a dual RNA-seq mapping procedure to survey the parasite transcripts found in RNA-seq samples from blood of visceral leishmaniasis patients. Diseased patients with active infection displayed the highest number of reads mapped to L. infantum genome. Even after six months later of the treatment, when the patients were considered cured, parasite reads were still detected. Parasite reads were also detected in asymptomatic individuals. The original dual RNA-seq alignment read count data provided here can be further explored to evaluate either host or parasite transcripts. (C) 2022 The Author(s). Published by Elsevier Inc. (AU)

• FAPESP's process: 16/20258-0 - Visceral leishmaniasis: genomics approaches for integrated molecular analysis of host and parasite
• Grantee: Sandra Regina Costa Maruyama
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 17/16328-6 - Visceral Leishmaniasis: genomics approaches for integrated molecular analysis of host and parasite.
• Grantee: Sandra Regina Costa Maruyama
• Support Opportunities: Scholarships in Brazil - Young Researchers
• FAPESP's process: 21/12464-8 - Developing molecular tools for the study of emerging parasites in Visceral Leishmaniasis
• Grantee: Nayore Tamie Takamiya
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 22/01525-9 - Tools for nucleic acid manipulation in samples of visceral leishmaniasis.
• Grantee: Ellen Gomes Alves
• Support Opportunities: Scholarships in Brazil - Technical Training Program - Technical Training
• FAPESP's process: 20/14011-8 - Phenotypic characterization and genomic analysis of Crithidia-like parasites obtained from patients diagnosed with Visceral Leishmaniasis
• Grantee: Luana Aparecida Rogerio
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 13/08216-2 - CRID - Center for Research in Inflammatory Diseases
• Grantee: Fernando de Queiroz Cunha
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 21/10358-6 - Genomic analysis of Leishmaniinae parasites isolated from human visceral Leishmaniasis
• Grantee: Caroline Torres
• Support Opportunities: Scholarships in Brazil - Scientific Initiation