| Full text | |
| Author(s): |
Scheffer, Debora da Luz
;
Garcia, Adriana Ann
;
Lee, Lucia
;
Mochly-Rosen, Daria
;
Ferreira, Julio Cesar Batista
Total Authors: 5
|
| Document type: | Journal article |
| Source: | Antioxidants & Redox Signaling; v. 36, n. 13, p. 20-pg., 2022-04-18. |
| Abstract | |
Significance: Mitochondria play a critical role in the physiology of the heart by controlling cardiac metabolism, function, and remodeling. Accumulation of fragmented and damaged mitochondria is a hallmark of cardiac diseases.Recent Advances: Disruption of quality control systems that maintain mitochondrial number, size, and shape through fission/fusion balance and mitophagy results in dysfunctional mitochondria, defective mitochondrial segregation, impaired cardiac bioenergetics, and excessive oxidative stress.Critical Issues: Pharmacological tools that improve the cardiac pool of healthy mitochondria through inhibition of excessive mitochondrial fission, boosting mitochondrial fusion, or increasing the clearance of damaged mitochondria have emerged as promising approaches to improve the prognosis of heart diseases.Future Directions: There is a reasonable amount of preclinical evidence supporting the effectiveness of molecules targeting mitochondrial fission and fusion to treat cardiac diseases. The current and future challenges are turning these lead molecules into treatments. Clinical studies focusing on acute (i.e., myocardial infarction) and chronic (i.e., heart failure) cardiac diseases are needed to validate the effectiveness of such strategies in improving mitochondrial morphology, metabolism, and cardiac function. (AU) | |
| FAPESP's process: | 15/22814-5 - Cancer and heart: new paradigms of diagnosis and treatment |
| Grantee: | Carlos Eduardo Negrão |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 19/25049-9 - Mitochondrial formyl peptides as signaling molecules in cardiac Ischemia-reperfusion injury |
| Grantee: | Julio Cesar Batista Ferreira |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/18627-3 - Mechanisms of exercise-induced mitophagy: a new avenue to drug discovery |
| Grantee: | Julio Cesar Batista Ferreira |
| Support Opportunities: | Scholarships abroad - Research |
| FAPESP's process: | 13/07937-8 - Redoxome - Redox Processes in Biomedicine |
| Grantee: | Ohara Augusto |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |