| Full text | |
| Author(s): |
Shahri, Atena Amanati
;
Omidvar, Amir Hossein
;
Rehder, Gustavo Pamplona
;
Caniato Serrano, Ariana Lacorte
Total Authors: 4
|
| Document type: | Journal article |
| Source: | SENSORS; v. 22, n. 9, p. 13-pg., 2022-05-01. |
| Abstract | |
A label-free, sensitive, miniaturized sensing device was developed for detecting living cells in their flow stream. The outstanding performance of this biosensor in distinguishing living cells in cell suspension was achieved by integrating microstrip stub resonator above a microfluidic structure using the metallic nanowire-filled membrane technology. The cell suspension flows in a microfluidic channel placed between the tip of the stub resonator and its ground plane as the substrate to take advantage of the uniform and concentrated field distribution. We studied the changes in relative permittivity due to the presence of a single living cell in the phase of the transmitted signal (S-21). An average variation of as much as 22.85 +/- 1.65 degrees at similar to 11.1 GHz is observed for the living cell sensing using this optimized device. This biosensor could detect rapid flowing cells in their biological medium in real-time and hence, can be used as an early diagnosis and monitoring tool for diseases. (AU) | |
| FAPESP's process: | 16/25779-9 - Multi-User Equipment aproved in grant 2012/15159-2: Vector Network Analyser (VNA) up to 70 GHz |
| Grantee: | Ariana Maria da Conceicao Lacorte Caniato Serrano |
| Support Opportunities: | Multi-user Equipment Program |
| FAPESP's process: | 18/08782-1 - Miniaturized and integrated chemical sensors: new fabrication platforms for biological, clinical and environmental applications |
| Grantee: | Mauro Bertotti |
| Support Opportunities: | Research Projects - Thematic Grants |