| Full text | |
| Author(s): Show less - |
Noronha, Natalia Yumi
;
Barato, Mariana
;
Sae-Lee, Chanachai
;
Pinhel, Marcela Augusta de Souza
;
Watanabe, Ligia Moriguchi
;
Pereira, Vanessa Aparecida Batista
;
Rodrigues, Guilherme da Silva
;
Morais, Deborah Araujo
;
de Sousa, Wellington Tavares
;
Souza, Vanessa Cristina de Oliveira
;
Placa, Jessica Rodrigues
;
Salgado Jr, Wilson
;
Barbosa, Fernando
;
Plosch, Torsten
;
Nonino, Carla Barbosa
Total Authors: 15
|
| Document type: | Journal article |
| Source: | FRONTIERS IN NUTRITION; v. 9, p. 10-pg., 2022-03-07. |
| Abstract | |
IntroductionNutriepigenetic markers are predictive responses associated with changes in "surrounding" environmental conditions of humans, which may influence metabolic diseases. Although rich in calories, Western diets could be linked with the deficiency of micronutrients, resulting in the downstream of epigenetic and metabolic effects and consequently in obesity. Zinc (Zn) is an essential nutrient associated with distinct biological roles in human health. Despite the importance of Zn in metabolic processes, little is known about the relationship between Zn and epigenetic. Thus, the present study aimed to identify the epigenetic variables associated with Zn daily ingestion (ZnDI) and serum Zinc (ZnS) levels in women with and without obesity. Materials and MethodsThis is a case-control, non-randomized, single-center study conducted with 21 women allocated into two groups: control group (CG), composed of 11 women without obesity, and study group (SG), composed of 10 women with obesity. Anthropometric measurements, ZnDI, and ZnS levels were evaluated. Also, leukocyte DNA was extracted for DNA methylation analysis using 450 k Illumina BeadChips. The epigenetic clock was calculated by Horvath method. The chip analysis methylation pipeline (ChAMP) package selected the differentially methylated regions (DMRs). ResultsThe SG had lower ZnS levels than the CG. Moreover, in SG, the ZnS levels were negatively associated with the epigenetic age acceleration. The DMR analysis revealed 37 DMRs associated with ZnDI and ZnS levels. The DMR of PM20D1 gene was commonly associated with ZnDI and ZnS levels and was hypomethylated in the SG. ConclusionOur findings provide new information on Zn's modulation of DNA methylation patterns and bring new perspectives for understanding the nutriepigenetic mechanisms in obesity. (AU) | |
| FAPESP's process: | 18/24069-3 - ReSEARCH: Recognizing Signatures of the Exposome to Anticipate the Risks for a Continuous Health |
| Grantee: | Fernando Barbosa Júnior |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 20/08687-9 - Selenium deficiency: identification of a risk profile considering genetic, clinical and environmental factors of patients with obesity in the pre and postoperative period of bariatric surgery |
| Grantee: | Lígia Moriguchi Watanabe |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |