A dopamine receptor D2 genetic polymorphism associated with transition to mental disorders in a cohort of individuals with at-risk mental state for psychosis

Author(s):Show less -

Julia Hatagami Marques ^[1] ; Leda Leme Talib ; Lucas Hortêncio ^[3] ; Julio Cesar Andrade ^[4] ; Tania Maria Alves ^[5] ; Mauricio Henriques Serpa ; Guilherme Lopes Yamamoto ; Martinus Theodorus van de Bilt ; Wulf Rössler ; Wagner Farid Gattaz ; Alexandre Andrade Loch

Affiliation:Show less -

^[1] Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP). Departamento de Psiquiatria. Laboratório de Neurociências (LIM-27) - Brasil

^[3] Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP). Departamento de Psiquiatria. Laboratório de Neurociências (LIM-27) - Brasil

^[4] Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP). Departamento de Psiquiatria. Laboratório de Neurociências (LIM-27) - Brasil

^[5] Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP). Departamento de Psiquiatria. Laboratório de Neurociências (LIM-27) - Brasil

• Document type: Journal article
• Source: Revista Brasileira de Psiquiatria; v. 45, n. 3, p. 268-273, 2023-07-03.

Abstract

Objectives: To test the association of 45 single nucleotide polymorphisms (SNPs) with transition to psychiatric disorders in a cohort of individuals at ultrahigh risk (UHR) mental state for psychosis. Methods: Through general population screening, 88 non-help-seeking UHR subjects and 130 healthy control individuals were genotyped for 45 SNPs related to psychosis. They were followed for a mean of 2.5 years, and conversion to psychotic and to general psychiatric disorders was assessed. Genotype frequencies between controls, converters, and non-converters were analyzed. Results: There were no differences in sociodemographics between controls and UHR. Also, UHR converters and non-converters had no differences in their baseline symptoms scores. The dopamine receptor D2 gene (DRD2) SNP rs6277 was significantly more common among UHR who transitioned to psychosis (p < 0.001) and to UHR who transitioned to any psychiatric disorders (p = 0.001) when compared to UHR who did not transition. The rs6277 T allele was related to psychiatric morbidity in a dose-response fashion, being significantly more frequent in UHR converters than UHR non-converters and control subjects (p = 0.003). Conclusion: Our findings suggest that rs6277 could potentially constitute a genetic marker of transition to psychiatric disorders in subjects with at-risk mental states, warranting further investigation in larger samples. (AU)

• FAPESP's process: 16/09069-1 - Follow-up of a cohort of individuals with ultra high risk for psychosis: assessment of genetic transition markers
• Grantee: Alexandre Andrade Loch
• Support Opportunities: Regular Research Grants