The use of omega-3 fatty acids in the treatment of oral diseases

Author(s)

Azuma, Mariane Maffei ; Morais Cardoso, Carolina de Barros ; da Silva, Cristiane Cantiga ; de Oliveira, Pedro Henrique Chaves ; Jacinto, Rogerio de Castilho ; Andrada, Ana Cristina ; Cintra, Luciano Tavares Angelo

• Document type: Journal article
• Source: ORAL DISEASES; v. 28, n. 2, p. 11-pg., 2020-10-27.

Abstract

Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) have been reported to exert important roles in the inflammatory response. There are many inflammatory diseases in dentistry which support the administration of omega-3 PUFAs as an adjunct therapy during the treatment of these diseases. The aim of this review was to evaluate the use of omega-3 PUFAs as an adjuvant therapy during the treatment of buccal diseases. The review showed that supplementation with omega-3 PUFAs was used for treatment of gingivitis, periodontal diseases, apical periodontitis, stomatitis, and orthodontic tooth movement. The results indicate that omega-3 PUFAs decreased the number of pro-inflammatory mediators in the gingival tissues of individuals with gingivitis and periodontitis. In apical periodontitis, the supplementation suppressed bone resorption and promoted bone formation in the periapical area of rats. During orthodontic movement, the supplementation showed a decrease of bone resorption in rats. It also showed that painful symptoms of recurrent aphthous stomatitis were alleviated in supplemented patients. In conclusion, the omega-3 PUFAs may be used as an adjuvant therapy in the treatment of inflammatory diseases that affect the oral cavity. However, more studies are required to elucidate the role of omega-3 PUFAs in decreasing oral cavity inflammatory processes. (AU)

• FAPESP's process: 15/03054-0 - The influence of dietary supplementation with ômega-3 fatty acids in the triglyceride levels and bone resorption in Wistar rats with endodontic infection
• Grantee: Carolina de Barros Morais Cardoso
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 13/26390-0 - Local and systemic influence of dietary supplementation with omega - 3 in rats with endodontic infection
• Grantee: Mariane Maffei Azuma
• Support Opportunities: Scholarships in Brazil - Doctorate